Literature DB >> 29410724

Chronic Skin Fragility of Aging: Current Concepts in the Pathogenesis, Recognition, and Management of Dermatoporosis.

Joseph M Dyer1, Richard A Miller1.   

Abstract

Thin skin and the appearance of bruises, seemingly unprovoked, are frequent complaints of elderly patients. Chronic cutaneous insufficiencies such as these are termed dermatoporosis. Although it is seldom the primary reason for consultation, dermatoporosis is associated with bleeding and healing complications and presents an opportunity for patient education and prevention. In this review, the authors explore the risk factors, pathogenetic mechanisms, clinical expression, and evidence-based therapies reported for chronic skin fragility due to aging.

Entities:  

Keywords:  CD44; Dermatoporosis; atrophic skin; chronic cutaneous insufficiency; geriatric dermatology; hyaluronic acid; senile purpura; skin fragility; skin tears

Year:  2018        PMID： 29410724      PMCID： PMC5788262     

Source DB:  PubMed          Journal:  J Clin Aesthet Dermatol        ISSN： 1941-2789


  48 in total

1.  Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation.

Authors:  G Kaya; I Rodriguez; J L Jorcano; P Vassalli; I Stamenkovic
Journal:  Genes Dev       Date:  1997-04-15       Impact factor: 11.361

2.  Citric acid increases viable epidermal thickness and glycosaminoglycan content of sun-damaged skin.

Authors:  E F Bernstein; C B Underhill; J Lakkakorpi; C M Ditre; J Uitto; R J Yu; E V Scott
Journal:  Dermatol Surg       Date:  1997-08       Impact factor: 3.398

3.  Involvement of dermal microvascular basement membrane in senile purpura: quantitative immunohistochemical study.

Authors:  R G Borroni; S Grassi; M Concardi; M Agozzino; C Caspani; C Giordano; M Vignini; E Arbustini
Journal:  J Eur Acad Dermatol Venereol       Date:  2015-09-25       Impact factor: 6.166

4.  On the effect of castration and peroral estrogen therapy on the skin.

Authors:  R Punnonen
Journal:  Acta Obstet Gynecol Scand Suppl       Date:  1971

5.  Epidermal and dermal effects of topical lactic acid.

Authors:  W P Smith
Journal:  J Am Acad Dermatol       Date:  1996-09       Impact factor: 11.527

Review 6.  Protein and older adults.

Authors:  Ronni Chernoff
Journal:  J Am Coll Nutr       Date:  2004-12       Impact factor: 3.169

Review 7.  Ultraviolet radiation-mediated damage to cellular DNA.

Authors:  Jean Cadet; Evelyne Sage; Thierry Douki
Journal:  Mutat Res       Date:  2005-01-26       Impact factor: 2.433

Review 8.  Dermatologic and cosmetic concerns of the older woman.

Authors:  J L Bolognia
Journal:  Clin Geriatr Med       Date:  1993-02       Impact factor: 3.076

9.  A randomized, double-blind, placebo-controlled study on the effect of conjugated estrogens on skin thickness.

Authors:  R Maheux; F Naud; M Rioux; R Grenier; A Lemay; J Guy; M Langevin
Journal:  Am J Obstet Gynecol       Date:  1994-02       Impact factor: 8.661

10.  Effects of topical DHEA on aging skin: a pilot study.

Authors:  Stéphanie Nouveau; Philippe Bastien; Francine Baldo; Olivier de Lacharriere
Journal:  Maturitas       Date:  2008-02-01       Impact factor: 4.342
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  12 in total

Review 1.  Factors Influencing Skin Aging and the Important Role of Estrogens and Selective Estrogen Receptor Modulators (SERMs).

Authors:  Edwin D Lephart; Frederick Naftolin
Journal:  Clin Cosmet Investig Dermatol       Date:  2022-08-19

2.  A retrospective cohort study of factors associated with severity of falls in hospital patients.

Authors:  Manonita Ghosh; Beverly O'Connell; Ebenezer Afrifa-Yamoah; Sue Kitchen; Linda Coventry
Journal:  Sci Rep       Date:  2022-07-18       Impact factor: 4.996

Review 3.  Estrogen Action and Gut Microbiome Metabolism in Dermal Health.

Authors:  Edwin D Lephart; Frederick Naftolin
Journal:  Dermatol Ther (Heidelb)       Date:  2022-06-25

Review 4.  Aquaporin-3 in the epidermis: more than skin deep.

Authors:  Wendy B Bollag; Lorry Aitkens; Joseph White; Kelly A Hyndman
Journal:  Am J Physiol Cell Physiol       Date:  2020-04-08       Impact factor: 4.249

Review 5.  Osteoporosis in Skin Diseases.

Authors:  Maria Maddalena Sirufo; Francesca De Pietro; Enrica Maria Bassino; Lia Ginaldi; Massimo De Martinis
Journal:  Int J Mol Sci       Date:  2020-07-03       Impact factor: 5.923

Review 6.  Neuroendocrine Aspects of Skin Aging.

Authors:  Georgeta Bocheva; Radomir M Slominski; Andrzej T Slominski
Journal:  Int J Mol Sci       Date:  2019-06-07       Impact factor: 5.923

7.  Use of a novel adhesive suture retention wound closure device to prevent patient follow-up visits during the COVID-19 pandemic.

Authors:  Lacey L Roybal; Stephanie Howerter; Brandon Markus; John Young; William Lear
Journal:  JAAD Case Rep       Date:  2020-05-01

Review 8.  Dermatoporosis - The Chronic Cutaneous Fragility Syndrome.

Authors:  Uwe Wollina; Torello Lotti; Aleksandra Vojvotic; Andreas Nowak
Journal:  Open Access Maced J Med Sci       Date:  2019-08-30

Review 9.  Wounding Therapies for Prevention of Photocarcinogenesis.

Authors:  Timothy C Frommeyer; Craig A Rohan; Dan F Spandau; Michael G Kemp; Molly A Wanner; Elizabeth Tanzi; Jeffrey B Travers
Journal:  Front Oncol       Date:  2022-01-07       Impact factor: 6.244

10.  A Recent Advance in the Closure of Skin Wounds on Fragile Skin.

Authors:  John Ko; Jeffrey S Freed
Journal:  Case Rep Emerg Med       Date:  2021-06-26
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