Monica G Lawrence1, John W Steinke2, Larry Borish3. 1. Asthma and Allergic Disease Center, University of Virginia Health System, Charlottesville, Virginia. 2. Asthma and Allergic Disease Center, University of Virginia Health System, Charlottesville, Virginia; Carter Center for Immunology Research, Charlottesville, Virginia. 3. Asthma and Allergic Disease Center, University of Virginia Health System, Charlottesville, Virginia; Carter Center for Immunology Research, Charlottesville, Virginia. Electronic address: lb4m@virginia.edu.
Abstract
OBJECTIVE: Asthma and allergic diseases continue to increase in prevalence, creating a financial burden on the health care system and affecting the quality of life for those who have these diseases. Many intrinsic and extrinsic factors are involved in the initiation and maintenance of the allergic response. Cytokines are proteins with growth, differentiation, and activation functions that regulate and direct the nature of immune responses. DATA SOURCES: clinicaltrials.gov and PubMed. STUDY SELECTIONS: Relevant clinical trials and recent basic science studies were chosen for discussion. RESULTS: Many cytokines have been implicated in the development and perpetuation of the allergic response. Biologics have been and are continuing to be developed that target these molecules for use in patients with asthma and atopic dermatitis where standard treatment options fail. The current state of cytokine-targeting therapies is discussed. CONCLUSION: This review focused on cytokines involved in the allergic response with an emphasis on those for which therapies are being or have been developed.
OBJECTIVE:Asthma and allergic diseases continue to increase in prevalence, creating a financial burden on the health care system and affecting the quality of life for those who have these diseases. Many intrinsic and extrinsic factors are involved in the initiation and maintenance of the allergic response. Cytokines are proteins with growth, differentiation, and activation functions that regulate and direct the nature of immune responses. DATA SOURCES: clinicaltrials.gov and PubMed. STUDY SELECTIONS: Relevant clinical trials and recent basic science studies were chosen for discussion. RESULTS: Many cytokines have been implicated in the development and perpetuation of the allergic response. Biologics have been and are continuing to be developed that target these molecules for use in patients with asthma and atopic dermatitis where standard treatment options fail. The current state of cytokine-targeting therapies is discussed. CONCLUSION: This review focused on cytokines involved in the allergic response with an emphasis on those for which therapies are being or have been developed.
Authors: Yujiao Meng; Zhengrong Liu; Chunyan Zhai; Tingting Di; Lu Zhang; Lei Zhang; Xinran Xie; Yan Lin; Ning Wang; Jingxia Zhao; Yan Wang; Ping Li Journal: Mol Med Rep Date: 2019-02-25 Impact factor: 2.952
Authors: Martijn J Schuijs; Shaun Png; Arianne C Richard; Anastasia Tsyben; Gregory Hamm; Julie Stockis; Celine Garcia; Silvain Pinaud; Ashley Nicholls; Xavier Romero Ros; Jing Su; Matthew D Eldridge; Angela Riedel; Eva M Serrao; Hans-Reimer Rodewald; Matthias Mack; Jacqueline D Shields; E Suzanne Cohen; Andrew N J McKenzie; Richard J A Goodwin; Kevin M Brindle; John C Marioni; Timotheus Y F Halim Journal: Nat Immunol Date: 2020-08-03 Impact factor: 25.606