| Literature DB >> 29409785 |
Irena Adkins1, Nada Hradilova2, Ondrej Palata2, Lenka Sadilkova3, Lenka Palova-Jelinkova4, Radek Spisek2.
Abstract
High hydrostatic pressure (HHP) has been known to affect biological systems for >100 years. In this review, we describe the technology of HHP and its effect macromolecules and physiology of eukaryotic cells. We discuss the use of HHP in cancer immunotherapy to kill tumor cells for generation of whole cell and dendritic cell-based vaccines. We further summarize the current use and perspectives of HHP application in biomedicine, specifically in orthopedic surgery and for the viral, microbial and protozoan inactivation to develop vaccines against infectious diseases.Entities:
Keywords: Cancer; Dendritic cell; High hydrostatic pressure; Immunotherapy; Orthopedic surgery; Vaccine; Virus inactivation
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Year: 2018 PMID： 29409785 DOI： 10.1016/j.biotechadv.2018.01.015
Source DB: PubMed Journal: Biotechnol Adv ISSN： 0734-9750 Impact factor: 14.227