Ji Sun Kim1,2, Yiyi Zhang3, Yoosoo Chang4,5,6, Seungho Ryu4,5,6, Eliseo Guallar3,5, Young-Chul Shin1,7, Hocheol Shin8, Se-Won Lim1,7, Juhee Cho3,4,5. 1. Workplace Mental Health Institute, Kangbuk Samsung Hospital, Seoul, Republic of Korea. 2. Department of Psychiatry, Soonchunhyang University Cheonan Hospital, Cheonan, Republic of Korea. 3. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. 4. Center for Cohort Study, Total Healthcare Center, Kangbuk Samsung Hospital, Seoul, Republic of Korea. 5. Department of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Republic of Korea. 6. Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. 7. Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. 8. Department of Family Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Abstract
Background: The role of subclinical hypothyroidism in the development of depression remains controversial. We examined the prospective association between subclinical hypothyroidism and incident depressive symptoms. Methods: We conducted a prospective cohort study of 220,545 middle-age adults without depression who had undergone at least two comprehensive health examinations between 1 January 2011 and 31 December 2014. Thyroid-stimulating hormone, free triiodothyronine (FT3), and free thyroxine (FT4) levels were measured using an electrochemiluminescent immunoassay. The study outcome was incident depressive symptoms, defined as a Center for Epidemiologic Studies-Depression score >16. Results: During a median follow-up period of 2 years, incident depressive symptoms occurred in 7323 participants. The multivariable-adjusted hazard ratio for incident depressive symptoms comparing subclinical hypothyroid and euthyroid participants was 0.97 (95% confidence interval, 0.87 to 1.09). Similarly, among euthyroid participants (n = 87,822), no apparent association was found between thyroid hormone levels and an increased risk of incident depressive symptoms. Conclusions: No apparent association was found between subclinical hypothyroidism and incident depressive symptoms in a large prospective cohort of middle-age men and women.
Background: The role of subclinical hypothyroidism in the development of depression remains controversial. We examined the prospective association between subclinical hypothyroidism and incident depressive symptoms. Methods: We conducted a prospective cohort study of 220,545 middle-age adults without depression who had undergone at least two comprehensive health examinations between 1 January 2011 and 31 December 2014. Thyroid-stimulating hormone, free triiodothyronine (FT3), and free thyroxine (FT4) levels were measured using an electrochemiluminescent immunoassay. The study outcome was incident depressive symptoms, defined as a Center for Epidemiologic Studies-Depression score >16. Results: During a median follow-up period of 2 years, incident depressive symptoms occurred in 7323 participants. The multivariable-adjusted hazard ratio for incident depressive symptoms comparing subclinical hypothyroid and euthyroid participants was 0.97 (95% confidence interval, 0.87 to 1.09). Similarly, among euthyroid participants (n = 87,822), no apparent association was found between thyroid hormone levels and an increased risk of incident depressive symptoms. Conclusions: No apparent association was found between subclinical hypothyroidism and incident depressive symptoms in a large prospective cohort of middle-age men and women.
Authors: Lea Wildisen; Elisavet Moutzouri; Shanthi Beglinger; Lamprini Syrogiannouli; Anne R Cappola; Bjørn O Åsvold; Stephan J L Bakker; Graziano Ceresini; Robin Dullaart; Luigi Ferrucci; Hans Grabe; J Wouter Jukema; Matthias Nauck; Stella Trompet; Henry Völzke; Rudi G J Westendorp; Jacobijn Gussekloo; Robin P Peeters; Stefan Klöppel; Drahomir Aujesky; Douglas C Bauer; Nicolas Rodondi; Cinzia Del Giovane; Martin Feller Journal: BMJ Open Date: 2019-07-26 Impact factor: 2.692
Authors: Ingrid Lieber; Michael Ott; Louise Öhlund; Robert Lundqvist; Mats Eliasson; Mikael Sandlund; Ursula Werneke Journal: J Psychopharmacol Date: 2019-10-31 Impact factor: 4.153
Authors: Lea Wildisen; Cinzia Del Giovane; Elisavet Moutzouri; Shanthi Beglinger; Lamprini Syrogiannouli; Tinh-Hai Collet; Anne R Cappola; Bjørn O Åsvold; Stephan J L Bakker; Bu B Yeap; Osvaldo P Almeida; Graziano Ceresini; Robin P F Dullaart; Luigi Ferrucci; Hans Grabe; J Wouter Jukema; Matthias Nauck; Stella Trompet; Henry Völzke; Rudi Westendorp; Jacobijn Gussekloo; Stefan Klöppel; Drahomir Aujesky; Douglas Bauer; Robin Peeters; Martin Feller; Nicolas Rodondi Journal: Sci Rep Date: 2020-11-05 Impact factor: 4.996