Yu Qiang Soh1,2, Jodhbir S Mehta1,2,3,4. 1. Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore. 2. Singapore National Eye Centre, Corneal and External Eye Disease Department, Singapore. 3. Ophthalmology Academic Clinical Program, Duke-NUS Graduate Medical School, Singapore. 4. Department of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore.
Abstract
PURPOSE: Peters anomaly is the most common cause of congenital corneal opacities. Although conservative management is often ineffective except in mild cases, surgical intervention in the form of penetrating keratoplasty is fraught with unpredictability and often has unacceptable postoperative outcomes. As such, there is a need to explore alternative surgical interventions that may possibly improve the postoperative visual prognosis in these patients. In this report, we present a case of type 1 Peters anomaly treated by selective endothelial removal without corneal tissue transplantation. METHODS: A case report with literature review. RESULTS: A 21-month-old child, who presented with unilateral type 1 Peters anomaly, underwent selective endothelial removal without corneal tissue transplantation for the treatment of her condition. The patient demonstrated excellent anatomical and visual recovery after the procedure over a 1-year period. Her visual acuity had improved from 20/960 preoperatively to 20/30 during the latest review. Postoperative recovery was not complicated by the development of any sight-threatening complications, and she has been successfully weaned off all topical and systemic medications. CONCLUSIONS: Selective endothelial removal can potentially be used to treat cases of type 1 Peters anomaly.
PURPOSE:Peters anomaly is the most common cause of congenital corneal opacities. Although conservative management is often ineffective except in mild cases, surgical intervention in the form of penetrating keratoplasty is fraught with unpredictability and often has unacceptable postoperative outcomes. As such, there is a need to explore alternative surgical interventions that may possibly improve the postoperative visual prognosis in these patients. In this report, we present a case of type 1 Peters anomaly treated by selective endothelial removal without corneal tissue transplantation. METHODS: A case report with literature review. RESULTS: A 21-month-old child, who presented with unilateral type 1 Peters anomaly, underwent selective endothelial removal without corneal tissue transplantation for the treatment of her condition. The patient demonstrated excellent anatomical and visual recovery after the procedure over a 1-year period. Her visual acuity had improved from 20/960 preoperatively to 20/30 during the latest review. Postoperative recovery was not complicated by the development of any sight-threatening complications, and she has been successfully weaned off all topical and systemic medications. CONCLUSIONS: Selective endothelial removal can potentially be used to treat cases of type 1 Peters anomaly.