Ebrahim Kouchaki1, Reza Daneshvar Kakhaki1, Omid Reza Tamtaji2, Ehsan Dadgostar3, Mohammad Behnam3, Hassan Nikoueinejad4, Hossein Akbari5. 1. Department of Neurology, Kashan University of Medical Sciences, Kashan, Iran. 2. Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran. Electronic address: tamtaji-or@kaums.ac.ir. 3. Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran. 4. Department of Immunology, Baqiyatallah University of Medical Sciences, Tehran, Iran; Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: hnikuinejad@bums.ac.ir. 5. Social Determinants of Health (SDH) Research Center, Kashan University of Medical Sciences, Kashan, Iran.
Abstract
OBJECTIVES: Immunological basis of neurodegenerative diseases including Alzheimer and Parkinson disease (PD) has some important roles in their pathogenesis. There are conflicting studies to serum level of TNF-α in PD. Also, according to our finding there is no report evaluating serum level of IL-27 in PD. This study correlates the serum level of those factors with severity of PD. PATIENTS AND METHODS: In this case-control study, 83 patients with PD and 83 healthy volunteers were enrolled. The diagnosis was fulfilled in accordance with clinical diagnostic criteria of the UK Parkinson's Disease Society Brain Bank by two neurologists. The modified Hoehn and Yahr (H and Y) scale was used to evaluate the severity of PD. Serum levels of TNF-α and IL-27 were measured by Elisa. Correlation of H and Y scale with serum levels of these cytokines was evaluated. RESULTS: The serum levels of TNF-α were increased and serum levels of IL-27 were decreased in patients with PD compared to those in healthy subjects (P < 0.0001). There was a significant correlation between serum levels of TNF-α and IL-27 with H and Y scale. CONCLUSION: Our study showed that the serum levels of TNF-α and IL-27 may be important prognostic biomarkers of PD.
OBJECTIVES: Immunological basis of neurodegenerative diseases including Alzheimer and Parkinson disease (PD) has some important roles in their pathogenesis. There are conflicting studies to serum level of TNF-α in PD. Also, according to our finding there is no report evaluating serum level of IL-27 in PD. This study correlates the serum level of those factors with severity of PD. PATIENTS AND METHODS: In this case-control study, 83 patients with PD and 83 healthy volunteers were enrolled. The diagnosis was fulfilled in accordance with clinical diagnostic criteria of the UK Parkinson's Disease Society Brain Bank by two neurologists. The modified Hoehn and Yahr (H and Y) scale was used to evaluate the severity of PD. Serum levels of TNF-α and IL-27 were measured by Elisa. Correlation of H and Y scale with serum levels of these cytokines was evaluated. RESULTS: The serum levels of TNF-α were increased and serum levels of IL-27 were decreased in patients with PD compared to those in healthy subjects (P < 0.0001). There was a significant correlation between serum levels of TNF-α and IL-27 with H and Y scale. CONCLUSION: Our study showed that the serum levels of TNF-α and IL-27 may be important prognostic biomarkers of PD.
Authors: Adithya Gopinath; Martin Badov; Madison Francis; Gerry Shaw; Anthony Collins; Douglas R Miller; Carissa A Hansen; Phillip Mackie; Malú Gámez Tansey; Abeer Dagra; Irina Madorsky; Adolfo Ramirez-Zamora; Michael S Okun; Wolfgang J Streit; Habibeh Khoshbouei Journal: NPJ Parkinsons Dis Date: 2021-07-20
Authors: Ivan N Vlasov; Anelya Kh Alieva; Ekaterina V Novosadova; Elena L Arsenyeva; Anna V Rosinskaya; Suzanna A Partevian; Igor A Grivennikov; Maria I Shadrina Journal: Cells Date: 2021-12-09 Impact factor: 6.600