Steve P Yu1, Bruce B Lee2, Michelle N Han3, Clara Chan3, Jianyu Rao3, Mary Levin3, Po Chu Fung3, William Parker3. 1. Departments of Obstetrics & Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA. Electronic address: spyu@mednet.ucla.edu. 2. Center for Uterine Fibroid Treatment, Southern California Hospital, Culver City, CA. 3. Departments of Obstetrics & Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Abstract
STUDY OBJECTIVE: To evaluate if copious irrigation and suctioning after electromechanical power morcellation will reduce myoma cell dissemination and if there is a difference between sterile water and normal saline. DESIGN: Prospective single-center cohort pilot study (Canadian Task Force classification II-2). SETTING: Academic tertiary referral center. PATIENTS: Sixteen women undergoing laparoscopic myomectomy with 1 surgeon between January 1, 2017 and August 31, 2017. INTERVENTIONS: Peritoneal washings were collected 3 specific times during surgery: after dissection of myoma(s) and hysterotomy repair but before morcellation, after morcellation, and after irrigation with 3 L normal saline or sterile water. The primary outcome was the detection of benign spindle cells (BSCs) in peritoneal washings. MEASUREMENTS AND MAIN RESULTS: Sixteen patients were enrolled in the study. Eight were randomized to the normal saline group and 8 to the sterile water group. In the normal saline group BSCs were detected in 3 of 8 patients (37.5%) after closure of the hysterotomy but before morcellation, in 3 of 8 (37.5%) after morcellation, and in 0 of 8 (0%) after irrigation and suctioning of the peritoneal cavity with 3 L normal saline. In the sterile water group BSCs were detected in 3 of 8 patients (37.5%) after closure of the hysterotomy but before morcellation, 2 of 8 (25%) after morcellation, and in 0 of 8 (0%) after irrigation and suctioning with 3 L sterile water. Thus, no differences were found between the normal saline and sterile water groups. CONCLUSION: In this pilot study myoma cells were disseminated before electromechanical morcellation. Irrigation and suctioning with 3 L normal saline or sterile water after morcellation may reduce myoma cell dissemination.
STUDY OBJECTIVE: To evaluate if copious irrigation and suctioning after electromechanical power morcellation will reduce myoma cell dissemination and if there is a difference between sterile water and normal saline. DESIGN: Prospective single-center cohort pilot study (Canadian Task Force classification II-2). SETTING: Academic tertiary referral center. PATIENTS: Sixteen women undergoing laparoscopic myomectomy with 1 surgeon between January 1, 2017 and August 31, 2017. INTERVENTIONS: Peritoneal washings were collected 3 specific times during surgery: after dissection of myoma(s) and hysterotomy repair but before morcellation, after morcellation, and after irrigation with 3 L normal saline or sterile water. The primary outcome was the detection of benign spindle cells (BSCs) in peritoneal washings. MEASUREMENTS AND MAIN RESULTS: Sixteen patients were enrolled in the study. Eight were randomized to the normal saline group and 8 to the sterile water group. In the normal saline group BSCs were detected in 3 of 8 patients (37.5%) after closure of the hysterotomy but before morcellation, in 3 of 8 (37.5%) after morcellation, and in 0 of 8 (0%) after irrigation and suctioning of the peritoneal cavity with 3 L normal saline. In the sterile water group BSCs were detected in 3 of 8 patients (37.5%) after closure of the hysterotomy but before morcellation, 2 of 8 (25%) after morcellation, and in 0 of 8 (0%) after irrigation and suctioning with 3 L sterile water. Thus, no differences were found between the normal saline and sterile water groups. CONCLUSION: In this pilot study myoma cells were disseminated before electromechanical morcellation. Irrigation and suctioning with 3 L normal saline or sterile water after morcellation may reduce myoma cell dissemination.
Authors: Michael Anapolski; Anja Schellenberger; Ibrahim Alkatout; Dimitrios Panayotopoulos; Alexander Gut; Stefan Soltesz; Sven Schiermeier; Thomas Papathemelis; Günter K Noé Journal: Sci Rep Date: 2021-10-22 Impact factor: 4.379