Literature DB >> 29408689

Updated follow-up of a tolerance protocol in HLA-identical renal transplant pairs given donor hematopoietic stem cells.

Joseph R Leventhal1, Joshua Miller1, James M Mathew2, Sunil Kurian3, Anat R Tambur1, John Friedewald4, Jane Charrette1, Michael M Abecassis5.   

Abstract

Kidney transplant recipients given donor hematopoietic stem cells from their HLA-identical living related donors have now been followed between 5 and 9½ years post-operatively. Recipients who were designated as tolerant (Tol) have remained so since the last report when the 5 year (biopsy associated) milestone was reached. There has been 1 mortality of a Tol patient, unrelated to the study protocol, while 5 (of 15) have remained Tol between 7 and 8½ years post-operatively. There has been continuing elevated T-regulatory (CD4+CD25HighCD127-FOXP3+) cells in PBMC previously reported on. Ten year renal transplant biopsies are tentatively planned.
Copyright © 2018 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Genomic markers; HLA-identical renal transplants; T and B regulatory cells; Tolerance

Mesh：

Substances：

Year:  2018        PMID： 29408689      PMCID： PMC5924714          DOI： 10.1016/j.humimm.2018.01.010

Source DB:  PubMed          Journal:  Hum Immunol        ISSN： 0198-8859            Impact factor:   2.850


  15 in total

1.  Identification of a B cell signature associated with renal transplant tolerance in humans.

Authors:  Kenneth A Newell; Adam Asare; Allan D Kirk; Trang D Gisler; Kasia Bourcier; Manikkam Suthanthiran; William J Burlingham; William H Marks; Ignacio Sanz; Robert I Lechler; Maria P Hernandez-Fuentes; Laurence A Turka; Vicki L Seyfert-Margolis
Journal:  J Clin Invest       Date:  2010-05-24       Impact factor: 14.808

2.  Favorable effects of alemtuzumab on allospecific regulatory T-cell generation.

Authors:  Josh Levitsky; Joseph R Leventhal; Joshua Miller; Xuemei Huang; Li Chen; Dhivya Chandrasekaran; Anat R Tambur; James M Mathew
Journal:  Hum Immunol       Date:  2011-11-23       Impact factor: 2.850

3.  Combined histocompatibility leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: the induction of allograft tolerance through mixed lymphohematopoietic chimerism.

Authors:  T R Spitzer; F Delmonico; N Tolkoff-Rubin; S McAfee; R Sackstein; S Saidman; C Colby; M Sykes; D H Sachs; A B Cosimi
Journal:  Transplantation       Date:  1999-08-27       Impact factor: 4.939

4.  Induced immune tolerance for kidney transplantation.

Authors:  John D Scandling; Stephan Busque; Judith A Shizuru; Edgar G Engleman; Samuel Strober
Journal:  N Engl J Med       Date:  2011-10-06       Impact factor: 91.245

5.  Long-term results with forty-five living related renal allograft recipients genotypically identical for HLA.

Authors:  H F Seigler; F E Ward; R E McCoy; J L Weinerth; J C Gunnells; D L Stickel
Journal:  Surgery       Date:  1977-03       Impact factor: 3.982

6.  Differential risks for adverse outcomes 3 years after kidney transplantation based on initial immunosuppression regimen: a national study.

Authors:  Vikas R Dharnidharka; Mark A Schnitzler; Jiajing Chen; Daniel C Brennan; David Axelrod; Dorry L Segev; Kenneth B Schechtman; Jie Zheng; Krista L Lentine
Journal:  Transpl Int       Date:  2016-09-28       Impact factor: 3.782

7.  HLA-mismatched renal transplantation without maintenance immunosuppression.

Authors:  Tatsuo Kawai; A Benedict Cosimi; Thomas R Spitzer; Nina Tolkoff-Rubin; Manikkam Suthanthiran; Susan L Saidman; Juanita Shaffer; Frederic I Preffer; Ruchuang Ding; Vijay Sharma; Jay A Fishman; Bimalangshu Dey; Dicken S C Ko; Martin Hertl; Nelson B Goes; Waichi Wong; Winfred W Williams; Robert B Colvin; Megan Sykes; David H Sachs
Journal:  N Engl J Med       Date:  2008-01-24       Impact factor: 91.245

8.  Tolerance and chimerism after renal and hematopoietic-cell transplantation.

Authors:  John D Scandling; Stephan Busque; Sussan Dejbakhsh-Jones; Claudia Benike; Maria T Millan; Judith A Shizuru; Richard T Hoppe; Robert Lowsky; Edgar G Engleman; Samuel Strober
Journal:  N Engl J Med       Date:  2008-01-24       Impact factor: 91.245

9.  Renal transplantation between HL-A identical donor-recipient pairs. Functional and morphological evaluation.

Authors:  H F Seigler; J C Gunnells; R R Robinson; F E Ward; D B Amos; D T Rowlands; P M Burkholder; W J Klein; D L Stickel
Journal:  J Clin Invest       Date:  1972-12       Impact factor: 14.808

10.  Genomic biomarkers correlate with HLA-identical renal transplant tolerance.

Authors:  Joseph R Leventhal; James M Mathew; Daniel R Salomon; Sunil M Kurian; Manikkam Suthanthiran; Anat Tambur; John Friedewald; Lorenzo Gallon; Jane Charette; Josh Levitsky; Yashpal Kanwar; Michael Abecassis; Joshua Miller
Journal:  J Am Soc Nephrol       Date:  2013-06-20       Impact factor: 10.121
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  5 in total

1.  Tolerance induction with donor hematopoietic stem cell infusion in kidney transplantation: a single-center experience in China with a 10-year follow-up.

Authors:  Xuanchuan Wang; Cheng Yang; Linkun Hu; Zheng Wei; Qunye Tang; Bing Chen; Yuan Ji; Ming Xu; Zhaochong Zeng; Ruiming Rong; Tongyu Zhu
Journal:  Ann Transl Med       Date:  2020-11

Review 2.  A Large-Scale Bank of Organ Donor Bone Marrow and Matched Mesenchymal Stem Cells for Promoting Immunomodulation and Transplant Tolerance.

Authors:  Brian H Johnstone; Franka Messner; Gerald Brandacher; Erik J Woods
Journal:  Front Immunol       Date:  2021-02-26       Impact factor: 7.561

Review 3.  Establishment of Chimerism and Organ Transplant Tolerance in Laboratory Animals: Safety and Efficacy of Adaptation to Humans.

Authors:  Robert Lowsky; Samuel Strober
Journal:  Front Immunol       Date:  2022-02-10       Impact factor: 7.561

4.  Pre-transplant infusion of donor leukocytes treated with extracorporeal photochemotherapy induces immune hypo-responsiveness and long-term allograft survival in murine models.

Authors:  Jennifer Schneiderman; Longhui Qiu; Xin Yi Yeap; Xin Kang; Feibo Zheng; Junsheng Ye; Yan Xie; Jiao-Jing Wang; Yuvaraj Sambandam; James Mathew; Lin Li; Joseph Leventhal; Richard L Edelson; Zheng Jenny Zhang
Journal:  Sci Rep       Date:  2022-05-04       Impact factor: 4.996

Review 5.  Cellular Therapies in Solid Organ Allotransplantation: Promise and Pitfalls.

Authors:  Brian I Shaw; Jeffrey R Ord; Chloe Nobuhara; Xunrong Luo
Journal:  Front Immunol       Date:  2021-08-30       Impact factor: 7.561
  5 in total

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