Yadi Lin1, Yunyan Wang2, Qin Wu3, Hua Jin4, Gaoxiang Ma1, Hanting Liu1, Meilin Wang1, Zhengdong Zhang5, Haiyan Chu6. 1. Department of Environmental Genomics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center For Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China; Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China. 2. Department of Urology, Huai-an First People's Hospital Affiliated to Nanjing Medical University, Huai-an, China. 3. Department of Medical Technology, Jiangsu Vocational College of Medicine, Yancheng, China. 4. Core Laboratory of Nantong Tumor Hospital, Nantong, China. 5. Department of Environmental Genomics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center For Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China; Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China. Electronic address: drzdzhang@njmu.edu.cn. 6. Department of Environmental Genomics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center For Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China; Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China. Electronic address: chy_grape@njmu.edu.cn.
Abstract
BACKGROUND: The association between obesity and bladder cancer prognosis is not well-defined. This meta-analysis was performed to explore whether obesity is related to overall survival (OS) and bladder cancer recurrence. METHODS: Relevant English-language studies were identified by searching PubMed® up to November 1, 2017. We pooled the hazard ratios (HR) and 95% confidence intervals (CIs) using a random effect model. Dose-response relationship, subgroup and sensitivity were also analyzed. RESULTS: Eleven studies were included. Recurrence rate of bladder cancer was significantly greater in obese (HR = 1.76, 95% CI: 1.36-2.28) vs normal weight patients. Stratification analysis showed that females had higher recurrence risk than males (HR = 1.17, 95% CI: 1.05-1.31). Obesity was not significantly associated with bladder cancer OS (HR = 1.21, 95% CI: 0.97-1.52). Dose-response relationship analysis revealed a linear association between BMI and risk of recurrence. Each one kg/m2 increase in BMI was related to a 1.3% increased risk of bladder cancer recurrence (HR = 1.01, 95% CI = 1.01 to 1.02). CONCLUSIONS: This meta-analysis revealed that obesity may be a risk factor for bladder cancer recurrence.
BACKGROUND: The association between obesity and bladder cancer prognosis is not well-defined. This meta-analysis was performed to explore whether obesity is related to overall survival (OS) and bladder cancer recurrence. METHODS: Relevant English-language studies were identified by searching PubMed® up to November 1, 2017. We pooled the hazard ratios (HR) and 95% confidence intervals (CIs) using a random effect model. Dose-response relationship, subgroup and sensitivity were also analyzed. RESULTS: Eleven studies were included. Recurrence rate of bladder cancer was significantly greater in obese (HR = 1.76, 95% CI: 1.36-2.28) vs normal weight patients. Stratification analysis showed that females had higher recurrence risk than males (HR = 1.17, 95% CI: 1.05-1.31). Obesity was not significantly associated with bladder cancer OS (HR = 1.21, 95% CI: 0.97-1.52). Dose-response relationship analysis revealed a linear association between BMI and risk of recurrence. Each one kg/m2 increase in BMI was related to a 1.3% increased risk of bladder cancer recurrence (HR = 1.01, 95% CI = 1.01 to 1.02). CONCLUSIONS: This meta-analysis revealed that obesity may be a risk factor for bladder cancer recurrence.
Authors: Lee Ingle; Samantha Ruilova; Yunsung Cui; Vanessa DeClercq; Ellen Sweeney; Zhijie Michael Yu; Cynthia C Forbes Journal: Cancer Causes Control Date: 2022-06-14 Impact factor: 2.532
Authors: Fawaz Dabea Alshammari; Hussain Gadelkarim Ahmed; Dena Alshammari; Ahmed Mulfy Alharbi; Atif Saud Alsaedi; Abdulbaset Elasbaly Journal: AIMS Public Health Date: 2019-01-23