Julio Costa1, Ana García-Blanco2, Yolanda Cañada1, María P García-Portilla3, Gemma Safont4, Belén Arranz5, Mónica Sanchez-Autet6, Lorenzo Livianos7, Victoria Fornés-Ferrer8, Pilar Sierra7. 1. Department of Psychiatry, La Fe University and Polytechnic Hospital, Valencia, Spain. 2. Neonatal Research Unit, La Fe Health Research Institute, Valencia, Spain. Electronic address: ana.garcia-blanco@uv.es. 3. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Department of Psychiatry, University of Oviedo, Oviedo, Spain. 4. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; University Hospital Mutua Terrassa, University of Barcelona, Department of Psychiatry, Spain. 5. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Parc Sanitari Sant Joan de Deu, Barcelona, Spain. 6. University Hospital Mutua Terrassa, University of Barcelona, Department of Psychiatry, Spain. 7. Department of Psychiatry, La Fe University and Polytechnic Hospital, Valencia, Spain; University of Valencia, Valencia, Spain. 8. Biostatistics Unit, Health Research Institute, Valencia, Spain.
Abstract
BACKGROUND: Bipolar disorder (BD) is a disabling illness that is associated with low quality of life (QoL). This low QoL goes further than mood episodes, which suggests that stable traits, such as affective temperaments, can cause functional impairment. OBJECTIVE: Our study analyses the impact of affective temperaments on the Physical Component Summary (PCS) and Mental Component Summary (MCS) of QoL in euthymic BD patients. METHODS: A multicentre study was conducted in 180 euthymic BD patients and 95 healthy controls. Firstly, statistical analyses were performed to compare QoL and affective temperaments between the two groups. Secondly, Adaptive Lasso Analysis was carried out to identify the potential confounding variables and select the affective temperaments as potential predictors on the PCS and MCS of QoL in BD patients, as well as the control group. RESULTS: QoL scores in terms of PCS and MCS in BD patients were significantly lower than in healthy individuals. Whereas anxious temperament, anxiety disorder comorbidity, and age were the best predictors of PCS impairment in BD patients, anxious temperament, subclinical depressive symptoms, and age were the best predictors of MCS impairment. LIMITATIONS: Further longitudinal studies with unaffected high-risk relatives are needed to examine the potential interaction between affective temperament and psychopathology. CONCLUSIONS: Anxious temperament has an impact on QoL in BD in terms of both the physical component and the mental component. Systematic screening of temperament in BD would give clinicians better knowledge of QoL predictors. Further research should allow more individualized treatment of BD patients based on temperamental factors.
BACKGROUND:Bipolar disorder (BD) is a disabling illness that is associated with low quality of life (QoL). This low QoL goes further than mood episodes, which suggests that stable traits, such as affective temperaments, can cause functional impairment. OBJECTIVE: Our study analyses the impact of affective temperaments on the Physical Component Summary (PCS) and Mental Component Summary (MCS) of QoL in euthymic BDpatients. METHODS: A multicentre study was conducted in 180 euthymic BDpatients and 95 healthy controls. Firstly, statistical analyses were performed to compare QoL and affective temperaments between the two groups. Secondly, Adaptive Lasso Analysis was carried out to identify the potential confounding variables and select the affective temperaments as potential predictors on the PCS and MCS of QoL in BDpatients, as well as the control group. RESULTS: QoL scores in terms of PCS and MCS in BDpatients were significantly lower than in healthy individuals. Whereas anxious temperament, anxiety disorder comorbidity, and age were the best predictors of PCS impairment in BDpatients, anxious temperament, subclinical depressive symptoms, and age were the best predictors of MCS impairment. LIMITATIONS: Further longitudinal studies with unaffected high-risk relatives are needed to examine the potential interaction between affective temperament and psychopathology. CONCLUSIONS: Anxious temperament has an impact on QoL in BD in terms of both the physical component and the mental component. Systematic screening of temperament in BD would give clinicians better knowledge of QoL predictors. Further research should allow more individualized treatment of BDpatients based on temperamental factors.
Authors: Alicja Popiołek; Bartosz Brzoszczyk; Piotr Jarzemski; Małgorzata Piskunowicz; Marcin Jarzemski; Alina Borkowska; Maciej Bieliński Journal: Cancer Manag Res Date: 2022-05-20 Impact factor: 3.602