Hideto Joki1, Yuichi Higashiyama1, Yoshiharu Nakae1, Chiharu Kugimoto1, Hiroshi Doi1, Katsuo Kimura2, Hitaru Kishida2, Naohisa Ueda2, Tatsu Nakano3, Tatsuya Takahashi4, Shigeru Koyano1, Hideyuki Takeuchi1, Fumiaki Tanaka5. 1. Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan. 2. Department of Neurology, Yokohama City University Medical Center, Yokohama, Japan. 3. Department of Neurology, Yokohama Sakae Kyosai Hospital, Yokohama, Japan. 4. Department of Neurology, National Hospital Organization Yokohama Medical Center, Yokohama, Japan. 5. Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan. Electronic address: ftanaka@yokohama-cu.ac.jp.
Abstract
BACKGROUND: In dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD), it is still debated whether white matter hyperintensities (WMH) on MRI reflect atherosclerotic cerebrovascular changes or Alzheimer's disease (AD)-related pathology such as cerebral amyloid angiopathy. To examine AD-related pathology in DLB and PDD, we compared the severity of WMH and medial temporal lobe atrophy among patients with DLB, PDD, non-demented PD (PDND), and AD. METHODS: We retrospectively studied sex- and age-matched outpatients with AD, DLB, PDD, and PDND, as well as subjects without central nervous system disorders as normal controls (n=50 each). All subjects underwent 1.5-T MRI examinations, and WMH detected by T2-weighted images or fluid-attenuated inversion recovery images were semiquantified according to the Fazekas method. Medial temporal lobe atrophy (MTA) was visually assessed by the MTA score. RESULTS: WMH were more prominent in AD, DLB, and PDD patients than in PDND patients and normal controls (NCs). DLB as well as AD showed more severe WMH than PDD. Visual assessment of medial temporal lobe atrophy showed that AD patients had the most severe atrophy, followed by DLB, PDD, and PDND patients, and NC subjects in that order. MTA scores showed significant correlations with WMH severity. CONCLUSION: Our results indicated that DLB was more similar to AD than to PDD in terms of MRI findings, suggesting that WMH in DLB may reflect mainly AD-related pathology rather than atherosclerotic cerebrovascular changes.
BACKGROUND: In dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD), it is still debated whether white matter hyperintensities (WMH) on MRI reflect atherosclerotic cerebrovascular changes or Alzheimer's disease (AD)-related pathology such as cerebral amyloid angiopathy. To examine AD-related pathology in DLB and PDD, we compared the severity of WMH and medial temporal lobe atrophy among patients with DLB, PDD, non-demented PD (PDND), and AD. METHODS: We retrospectively studied sex- and age-matched outpatients with AD, DLB, PDD, and PDND, as well as subjects without central nervous system disorders as normal controls (n=50 each). All subjects underwent 1.5-T MRI examinations, and WMH detected by T2-weighted images or fluid-attenuated inversion recovery images were semiquantified according to the Fazekas method. Medial temporal lobe atrophy (MTA) was visually assessed by the MTA score. RESULTS:WMH were more prominent in AD, DLB, and PDDpatients than in PDND patients and normal controls (NCs). DLB as well as AD showed more severe WMH than PDD. Visual assessment of medial temporal lobe atrophy showed that ADpatients had the most severe atrophy, followed by DLB, PDD, and PDND patients, and NC subjects in that order. MTA scores showed significant correlations with WMH severity. CONCLUSION: Our results indicated that DLB was more similar to AD than to PDD in terms of MRI findings, suggesting that WMH in DLB may reflect mainly AD-related pathology rather than atherosclerotic cerebrovascular changes.
Authors: Taylor Kuhn; Sergio Becerra; John Duncan; Norman Spivak; Bianca Huan Dang; Barshen Habelhah; Kennedy D Mahdavi; Michael Mamoun; Michael Whitney; F Scott Pereles; Alexander Bystritsky; Sheldon E Jordan Journal: Quant Imaging Med Surg Date: 2021-09
Authors: Michael T Grey; Kristína Mitterová; Martin Gajdoš; Richard Uher; Patrícia Klobušiaková; Irena Rektorová; Ivan Rektor Journal: J Neural Transm (Vienna) Date: 2022-07-11 Impact factor: 3.850
Authors: Daniel Ferreira; Zuzana Nedelska; Jonathan Graff-Radford; Scott A Przybelski; Timothy G Lesnick; Christopher G Schwarz; Hugo Botha; Matthew L Senjem; Julie A Fields; David S Knopman; Rodolfo Savica; Tanis J Ferman; Neill R Graff-Radford; Val J Lowe; Clifford R Jack; Ronald C Petersen; Afina W Lemstra; Marleen van de Beek; Frederik Barkhof; Frederic Blanc; Paulo Loureiro de Sousa; Nathalie Philippi; Benjamin Cretin; Catherine Demuynck; Jakub Hort; Ketil Oppedal; Bradley F Boeve; Dag Aarsland; Eric Westman; Kejal Kantarci Journal: Neurobiol Aging Date: 2021-05-14 Impact factor: 5.133