Joline E Brandenburg1, Sarah F Eby, Pengfei Song, William R Bamlet, Gary C Sieck, Kai-Nan An. 1. From the Department of Physical Medicine and Rehabilitation (JEB), Department of Neurology (JEB), Department of Pediatric and Adolescent Medicine (JEB), Mayo Graduate School, Medical Scientist Training Program, Mayo Clinic College of Medicine (SFE), Department of Radiology (PS), Department of Health Sciences Research (WRB), Department of Physiology and Biomedical Engineering (GCS, K-NA), and Division of Orthopedic Research (K-NA), Mayo Clinic, Rochester, Minnesota.
Abstract
OBJECTIVE: A pilot study was conducted to longitudinally quantify effect of onabotulinum toxin A (BoNT-A) on passive muscle properties in children with cerebral palsy using ultrasound shear wave elastography. DESIGN: This was a prospective longitudinal cohort study. RESULTS: Between 1 and 3 mos post-BoNT-A, a significant improvement in the shear modulus of the lateral gastrocnemius was found at 10-degrees plantar flexion (PF) (-7.57 [-10.98, -5.07], P = 0.02) and 0-degrees PF (-14.74 [-18.21, -9.38], P = 0.03). There was a notable, but nonsignificant, difference in shear modulus at 20-degrees PF, 10-degrees PF, and 0-degrees PF between pre-BoNT-A and 1 mo post-BoNT-A. Pre-BoNT-A shear modulus was not significantly different from 3 mos post-BoNT-A at all foot positions. No significant differences in ankle passive range of motion or spasticity were found. CONCLUSION: Despite no significant change in ankle range of motion or spasticity, shear wave elastography was able to detect a difference in lateral gastrocnemius passive muscle properties in children with cerebral palsy after BoNT-A injections. The difference in passive muscle properties resolved by 3 mos post-BoNT-A.
OBJECTIVE: A pilot study was conducted to longitudinally quantify effect of onabotulinum toxin A (BoNT-A) on passive muscle properties in children with cerebral palsy using ultrasound shear wave elastography. DESIGN: This was a prospective longitudinal cohort study. RESULTS: Between 1 and 3 mos post-BoNT-A, a significant improvement in the shear modulus of the lateral gastrocnemius was found at 10-degrees plantar flexion (PF) (-7.57 [-10.98, -5.07], P = 0.02) and 0-degrees PF (-14.74 [-18.21, -9.38], P = 0.03). There was a notable, but nonsignificant, difference in shear modulus at 20-degrees PF, 10-degrees PF, and 0-degrees PF between pre-BoNT-A and 1 mo post-BoNT-A. Pre-BoNT-A shear modulus was not significantly different from 3 mos post-BoNT-A at all foot positions. No significant differences in ankle passive range of motion or spasticity were found. CONCLUSION: Despite no significant change in ankle range of motion or spasticity, shear wave elastography was able to detect a difference in lateral gastrocnemius passive muscle properties in children with cerebral palsy after BoNT-A injections. The difference in passive muscle properties resolved by 3 mos post-BoNT-A.
Authors: Joline E Brandenburg; Sarah F Eby; Pengfei Song; Heng Zhao; Jeffrey S Brault; Shigao Chen; Kai-Nan An Journal: Arch Phys Med Rehabil Date: 2014-07-24 Impact factor: 3.966
Authors: Adel A A Alhusaini; Jack Crosbie; Roberta B Shepherd; Catherine M Dean; Adam Scheinberg Journal: Dev Med Child Neurol Date: 2011-06 Impact factor: 5.449
Authors: Joline E Brandenburg; Sarah F Eby; Pengfei Song; Shirley Kingsley-Berg; William Bamlet; Gary C Sieck; Kai-Nan An Journal: Dev Med Child Neurol Date: 2016-07-04 Impact factor: 5.449
Authors: Anna E Knight; Courtney A Trutna; Ned C Rouze; Lisa D Hobson-Webb; Annette Caenen; Felix Q Jin; Mark L Palmeri; Kathryn R Nightingale Journal: IEEE Trans Med Imaging Date: 2021-12-30 Impact factor: 10.048