Literature DB >> 29405929

Discovery of Hypocretin/Orexin Ushers in a New Era of Sleep Research.

David A Prober1.   

Abstract

Prior to the 21st century, genetic mechanisms that regulate sleep were largely unknown. In 1998, de Lecea et al. [1] (Proc. Natl. Acad. Sci. U. S. A. 1998; 95:322-327) and Sakurai et al. [2] (Cell 1998; 92: 573-585) reported the discovery of a gene they named hypocretin and orexin, respectively, which led to a revolution in our understanding of genetic and neuronal mechanisms that regulate sleep.
Copyright © 2017 Elsevier Ltd. All rights reserved.

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Keywords:  arousal; hypocretin; orexin; sleep

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Year:  2018        PMID： 29405929      PMCID： PMC5805467          DOI： 10.1016/j.tins.2017.11.007

Source DB:  PubMed          Journal:  Trends Neurosci        ISSN： 0166-2236            Impact factor:   13.837


  15 in total

1.  The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene.

Authors:  L Lin; J Faraco; R Li; H Kadotani; W Rogers; X Lin; X Qiu; P J de Jong; S Nishino; E Mignot
Journal:  Cell       Date:  1999-08-06       Impact factor: 41.582

2.  Overview of the most prevalent hypothalamus-specific mRNAs, as identified by directional tag PCR subtraction.

Authors:  K M Gautvik; L de Lecea; V T Gautvik; P E Danielson; P Tranque; A Dopazo; F E Bloom; J G Sutcliffe
Journal:  Proc Natl Acad Sci U S A       Date:  1996-08-06       Impact factor: 11.205

3.  The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.

Authors:  L de Lecea; T S Kilduff; C Peyron; X Gao; P E Foye; P E Danielson; C Fukuhara; E L Battenberg; V T Gautvik; F S Bartlett; W N Frankel; A N van den Pol; F E Bloom; K M Gautvik; J G Sutcliffe
Journal:  Proc Natl Acad Sci U S A       Date:  1998-01-06       Impact factor: 11.205

4.  Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

Authors:  T Sakurai; A Amemiya; M Ishii; I Matsuzaki; R M Chemelli; H Tanaka; S C Williams; J A Richardson; G P Kozlowski; S Wilson; J R Arch; R E Buckingham; A C Haynes; S A Carr; R S Annan; D E McNulty; W S Liu; J A Terrett; N A Elshourbagy; D J Bergsma; M Yanagisawa
Journal:  Cell       Date:  1998-02-20       Impact factor: 41.582

Review 5.  Unraveling the Evolutionary Determinants of Sleep.

Authors:  William J Joiner
Journal:  Curr Biol       Date:  2016-10-24       Impact factor: 10.834

6.  Orexin A activates locus coeruleus cell firing and increases arousal in the rat.

Authors:  J J Hagan; R A Leslie; S Patel; M L Evans; T A Wattam; S Holmes; C D Benham; S G Taylor; C Routledge; P Hemmati; R P Munton; T E Ashmeade; A S Shah; J P Hatcher; P D Hatcher; D N Jones; M I Smith; D C Piper; A J Hunter; R A Porter; N Upton
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-14       Impact factor: 11.205

7.  Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation.

Authors:  R M Chemelli; J T Willie; C M Sinton; J K Elmquist; T Scammell; C Lee; J A Richardson; S C Williams; Y Xiong; Y Kisanuki; T E Fitch; M Nakazato; R E Hammer; C B Saper; M Yanagisawa
Journal:  Cell       Date:  1999-08-20       Impact factor: 41.582

8.  Neural substrates of awakening probed with optogenetic control of hypocretin neurons.

Authors:  Antoine R Adamantidis; Feng Zhang; Alexander M Aravanis; Karl Deisseroth; Luis de Lecea
Journal:  Nature       Date:  2007-10-17       Impact factor: 49.962

9.  Forward-genetics analysis of sleep in randomly mutagenized mice.

Authors:  Hiromasa Funato; Chika Miyoshi; Tomoyuki Fujiyama; Takeshi Kanda; Makito Sato; Zhiqiang Wang; Jing Ma; Shin Nakane; Jun Tomita; Aya Ikkyu; Miyo Kakizaki; Noriko Hotta-Hirashima; Satomi Kanno; Haruna Komiya; Fuyuki Asano; Takato Honda; Staci J Kim; Kanako Harano; Hiroki Muramoto; Toshiya Yonezawa; Seiya Mizuno; Shinichi Miyazaki; Linzi Connor; Vivek Kumar; Ikuo Miura; Tomohiro Suzuki; Atsushi Watanabe; Manabu Abe; Fumihiro Sugiyama; Satoru Takahashi; Kenji Sakimura; Yu Hayashi; Qinghua Liu; Kazuhiko Kume; Shigeharu Wakana; Joseph S Takahashi; Masashi Yanagisawa
Journal:  Nature       Date:  2016-11-02       Impact factor: 49.962

10.  Reduced number of hypocretin neurons in human narcolepsy.

Authors:  T C Thannickal; R Y Moore; R Nienhuis; L Ramanathan; S Gulyani; M Aldrich; M Cornford; J M Siegel
Journal:  Neuron       Date:  2000-09       Impact factor: 17.173
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  2 in total

1.  A randomized placebo-controlled double-blind study of dexmedetomidine on postoperative sleep quality in patients with endoscopic sinus surgery.

Authors:  Yu Wu; Yuhua Miao; Xuzhen Chen; Xiaojian Wan
Journal:  BMC Anesthesiol       Date:  2022-06-01       Impact factor: 2.376

2.  Unique transcriptional signatures of sleep loss across independently evolved cavefish populations.

Authors:  Suzanne E McGaugh; Courtney N Passow; James Brian Jaggard; Bethany A Stahl; Alex C Keene
Journal:  J Exp Zool B Mol Dev Evol       Date:  2020-04-29       Impact factor: 2.656
  2 in total

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