| Literature DB >> 29404828 |
Daniel Cadena-Sandoval1,2, Isidro Alemán-Ávila1, Rosa Elda Barbosa-Cobos3, Lizbeth Teresa Becerril-Mendoza3, José Manuel Fragoso4, Julián Ramírez-Bello5.
Abstract
Tumor necrosis factor (TNF) plays an important role in the pathogenesis of rheumatoid arthritis (RA). Different genetic variants including the TNF -308G/A polymorphism are associated with RA susceptibility. However, these findings have not been replicated in all populations. The aim of this study was to determine whether the TNF -1031T/C (rs1799964), -376G/A (rs1800750), -308G/A (rs1800629) -238G/A (rs361525), and TNFR1 -609G/T polymorphisms are associated with RA susceptibility in a sample of Mexican patients. Our study included 499 patients with RA and 492 healthy controls. The genotypes of the TNF polymorphisms were obtained using TaqMan assay. The genotype and allele frequencies of the TNF -1031T/C, -376G/A, -308G/A, -238G/A, and TNFR1 -609G/T polymorphisms were similar among RA cases versus healthy controls, and no association with RA susceptibility was identified. Our results suggest that the TNF -1031T/C, -376G/A, -308G/A, -238G/A, and TNFR1 -609G/T polymorphisms are not associated with RA susceptibility in a sample of Mexican patients.Entities:
Keywords: Rheumatoid arthritis; Single nucleotide polymorphism; Susceptibility; Tumor necrosis factor
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Year: 2018 PMID： 29404828 DOI： 10.1007/s11033-018-4155-2
Source DB: PubMed Journal: Mol Biol Rep ISSN： 0301-4851 Impact factor: 2.316