Literature DB >> 29404399

The turtle and the rabbit story in a modern (PI3)key.

Miriam Martini1, Maria Chiara De Santis1, Emilio Hirsch1.   

Abstract

Mitosis is a complex process controlling proper distribution of chromosomes and preventing genomic instability, a typical hallmark of cancer. We recently reported that that a class II isoform of Phosphoinositide 3-kinase (PI3K), PI3K-C2α, is involved in the organization of the mitotic spindle. Our study demonstrate that, differently to all other PI3K isoforms, PI3K-C2α shows an unexpected tumor suppressor function independent of its catalytic activity.

Entities:  

Keywords:  Metaphase; anti-microtubules agents; breast cancer; class II PI3Ks; spindle

Year:  2017        PMID： 29404399      PMCID： PMC5791862          DOI： 10.1080/23723556.2017.1405141

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  The centrosome and mitotic spindle apparatus in cancer and senescence.

Authors:  Stephen Schmidt; Frank Essmann; Ion C Cirstea; Fabian Kuck; Harish C Thakur; Madhurendra Singh; Anja Kletke; Reiner U Jänicke; Constanze Wiek; Helmut Hanenberg; M Reza Ahmadian; Klaus Schulze-Osthoff; Bernd Nürnberg; Roland P Piekorz
Journal:  Cell Cycle       Date:  2010-11-15       Impact factor: 4.534

Review 2.  The PI3K Pathway in Human Disease.

Authors:  David A Fruman; Honyin Chiu; Benjamin D Hopkins; Shubha Bagrodia; Lewis C Cantley; Robert T Abraham
Journal:  Cell       Date:  2017-08-10       Impact factor: 41.582

3.  Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension.

Authors:  Liam P Cheeseman; Edward F Harry; Andrew D McAinsh; Ian A Prior; Stephen J Royle
Journal:  J Cell Sci       Date:  2013-03-26       Impact factor: 5.285

4.  mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate.

Authors:  Andrea L Marat; Alexander Wallroth; Wen-Ting Lo; Rainer Müller; Giuseppe Danilo Norata; Marco Falasca; Carsten Schultz; Volker Haucke
Journal:  Science       Date:  2017-06-02       Impact factor: 47.728

5.  Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate.

Authors:  York Posor; Marielle Eichhorn-Gruenig; Dmytro Puchkov; Johannes Schöneberg; Alexander Ullrich; André Lampe; Rainer Müller; Sirus Zarbakhsh; Federico Gulluni; Emilio Hirsch; Michael Krauss; Carsten Schultz; Jan Schmoranzer; Frank Noé; Volker Haucke
Journal:  Nature       Date:  2013-07-03       Impact factor: 49.962

6.  A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging.

Authors:  Daniel G Booth; Fiona E Hood; Ian A Prior; Stephen J Royle
Journal:  EMBO J       Date:  2011-02-04       Impact factor: 11.598

7.  Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function.

Authors:  Federico Gulluni; Miriam Martini; Maria Chiara De Santis; Carlo Cosimo Campa; Alessandra Ghigo; Jean Piero Margaria; Elisa Ciraolo; Irene Franco; Ugo Ala; Laura Annaratone; Davide Disalvatore; Giovanni Bertalot; Giuseppe Viale; Anna Noatynska; Mara Compagno; Sara Sigismund; Filippo Montemurro; Marcus Thelen; Fan Fan; Patrick Meraldi; Caterina Marchiò; Salvatore Pece; Anna Sapino; Roberto Chiarle; Pier Paolo Di Fiore; Emilio Hirsch
Journal:  Cancer Cell       Date:  2017-10-09       Impact factor: 31.743

8.  PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling.

Authors:  Laura Braccini; Elisa Ciraolo; Carlo C Campa; Alessia Perino; Dario L Longo; Gianpaolo Tibolla; Marco Pregnolato; Yanyan Cao; Beatrice Tassone; Federico Damilano; Muriel Laffargue; Enzo Calautti; Marco Falasca; Giuseppe D Norata; Jonathan M Backer; Emilio Hirsch
Journal:  Nat Commun       Date:  2015-06-23       Impact factor: 14.919

9.  Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity.

Authors:  Samira Alliouachene; Benoit Bilanges; Gaëtan Chicanne; Karen E Anderson; Wayne Pearce; Khaled Ali; Colin Valet; York Posor; Pei Ching Low; Claire Chaussade; Cheryl L Scudamore; Rachel S Salamon; Jonathan M Backer; Len Stephens; Phill T Hawkins; Bernard Payrastre; Bart Vanhaesebroeck
Journal:  Cell Rep       Date:  2015-11-19       Impact factor: 9.423

10.  PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function.

Authors:  Irene Franco; Federico Gulluni; Carlo C Campa; Carlotta Costa; Jean Piero Margaria; Elisa Ciraolo; Miriam Martini; Daniel Monteyne; Elisa De Luca; Giulia Germena; York Posor; Tania Maffucci; Stefano Marengo; Volker Haucke; Marco Falasca; David Perez-Morga; Alessandra Boletta; Giorgio R Merlo; Emilio Hirsch
Journal:  Dev Cell       Date:  2014-03-31       Impact factor: 12.270
  10 in total

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