Literature DB >> 29404394

To die or not to die: Regulatory feedback phosphorylation circuits determine receptor-interacting protein kinase-1 (RIPK1) function.

Manoj B Menon1, Julia Gropengießer2, Klaus Ruckdeschel2, Matthias Gaestel1.   

Abstract

Complex posttranslational modifications determine the effects of receptor-interacting protein kinase-1 (RIPK1) on cell survival and death. Studies from us and others have revealed a p38MAPK/MK2-dependent checkpoint in RIPK1 signaling. MAPKAP kinase 2 (MK2) phosphorylates RIPK1 to suppress RIPK1-mediated apoptosis and necroptosis in response to diverse stimuli relevant to inflammation, infection, genotoxic stress and chemotherapy.

Entities:  

Keywords:  MK2; RIPK1; cell death; phosphorylation; signal transduction

Year:  2017        PMID： 29404394      PMCID： PMC5791865          DOI： 10.1080/23723556.2017.1396389

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling.

Authors:  Yves Dondelinger; Sandrine Jouan-Lanhouet; Tatyana Divert; Emilie Theatre; John Bertin; Peter J Gough; Piero Giansanti; Albert J R Heck; Emmanuel Dejardin; Peter Vandenabeele; Mathieu J M Bertrand
Journal:  Mol Cell       Date:  2015-09-03       Impact factor: 17.970

Review 2.  MAPKAP kinases - MKs - two's company, three's a crowd.

Authors:  Matthias Gaestel
Journal:  Nat Rev Mol Cell Biol       Date:  2006-02       Impact factor: 94.444

Review 3.  Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death.

Authors:  Dimitry Ofengeim; Junying Yuan
Journal:  Nat Rev Mol Cell Biol       Date:  2013-10-16       Impact factor: 94.444

Review 4.  Crosstalk in NF-κB signaling pathways.

Authors:  Andrea Oeckinghaus; Matthew S Hayden; Sankar Ghosh
Journal:  Nat Immunol       Date:  2011-07-19       Impact factor: 25.606

5.  MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death.

Authors:  Yves Dondelinger; Tom Delanghe; Diego Rojas-Rivera; Dario Priem; Tinneke Delvaeye; Inge Bruggeman; Franky Van Herreweghe; Peter Vandenabeele; Mathieu J M Bertrand
Journal:  Nat Cell Biol       Date:  2017-09-18       Impact factor: 28.824

6.  A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage.

Authors:  Yibin Yang; Fang Xia; Nicole Hermance; Angela Mabb; Sara Simonson; Sarah Morrissey; Pallavi Gandhi; Mary Munson; Shigeki Miyamoto; Michelle A Kelliher
Journal:  Mol Cell Biol       Date:  2011-05-23       Impact factor: 4.272

7.  p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection.

Authors:  Manoj B Menon; Julia Gropengießer; Jessica Fischer; Lena Novikova; Anne Deuretzbacher; Juri Lafera; Hanna Schimmeck; Nicole Czymmeck; Natalia Ronkina; Alexey Kotlyarov; Martin Aepfelbacher; Matthias Gaestel; Klaus Ruckdeschel
Journal:  Nat Cell Biol       Date:  2017-09-18       Impact factor: 28.824

8.  Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics.

Authors:  Najoua Lalaoui; Kay Hänggi; Gabriela Brumatti; Diep Chau; Nhu-Y N Nguyen; Lazaros Vasilikos; Lisanne M Spilgies; Denise A Heckmann; Chunyan Ma; Margherita Ghisi; Jessica M Salmon; Geoffrey M Matthews; Elisha de Valle; Donia M Moujalled; Manoj B Menon; Sukhdeep Kaur Spall; Stefan P Glaser; Jennifer Richmond; Richard B Lock; Stephen M Condon; Raffi Gugasyan; Matthias Gaestel; Mark Guthridge; Ricky W Johnstone; Lenka Munoz; Andrew Wei; Paul G Ekert; David L Vaux; W Wei-Lynn Wong; John Silke
Journal:  Cancer Cell       Date:  2016-02-08       Impact factor: 31.743

9.  The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs.

Authors:  Tencho Tenev; Katiuscia Bianchi; Maurice Darding; Meike Broemer; Claudia Langlais; Fredrik Wallberg; Anna Zachariou; Juanita Lopez; Marion MacFarlane; Kelvin Cain; Pascal Meier
Journal:  Mol Cell       Date:  2011-07-07       Impact factor: 17.970

10.  MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death.

Authors:  Isabel Jaco; Alessandro Annibaldi; Najoua Lalaoui; Rebecca Wilson; Tencho Tenev; Lucie Laurien; Chun Kim; Kunzah Jamal; Sidonie Wicky John; Gianmaria Liccardi; Diep Chau; James M Murphy; Gabriela Brumatti; Rebecca Feltham; Manolis Pasparakis; John Silke; Pascal Meier
Journal:  Mol Cell       Date:  2017-05-11       Impact factor: 17.970
  10 in total
  1 in total

1.  Molecular Mechanisms of the Toll-Like Receptor, STING, MAVS, Inflammasome, and Interferon Pathways.

Authors:  Nathan P Manes; Aleksandra Nita-Lazar
Journal:  mSystems       Date:  2021-06-29       Impact factor: 6.496
  1 in total

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