Literature DB >> 29404387

MICAL redox enzymes and actin remodeling: New links to classical tumorigenic and cancer pathways.

Jimok Yoon1,2, Jonathan R Terman1.   

Abstract

MICAL Redox enzymes have recently emerged as direct regulators of cell shape and motility - working through specific reversible post-translational oxidation of actin to disassemble and remodel the cytoskeleton. Links are also now emerging between MICALs and cancer, including our recent results that regulation of MICAL sensitizes cancer cells to the cancer drug Gleevec. Targeting this new actin regulatory enzyme system may thus provide new therapeutic options for cancer treatment.

Entities:  

Keywords:  Abl; Attraction; Chemotropic; Growth Factors; Kinase; Phosphorylation; Plexins; Post-translational Modification; Repulsion; Semaphorins

Year:  2017        PMID： 29404387      PMCID： PMC5791864          DOI： 10.1080/23723556.2017.1384881

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Mechanisms and molecules of neuronal wiring: a primer.

Authors:  Alex L Kolodkin; Marc Tessier-Lavigne
Journal:  Cold Spring Harb Perspect Biol       Date:  2011-06-01       Impact factor: 10.005

Review 2.  Actin filaments-A target for redox regulation.

Authors:  Carlos Wilson; Jonathan R Terman; Christian González-Billault; Giasuddin Ahmed
Journal:  Cytoskeleton (Hoboken)       Date:  2016-08-06

3.  Direct redox regulation of F-actin assembly and disassembly by Mical.

Authors:  Ruei-Jiun Hung; Chi W Pak; Jonathan R Terman
Journal:  Science       Date:  2011-11-24       Impact factor: 47.728

4.  Mical links semaphorins to F-actin disassembly.

Authors:  Ruei-Jiun Hung; Umar Yazdani; Jimok Yoon; Heng Wu; Taehong Yang; Nidhi Gupta; Zhiyu Huang; Willem J H van Berkel; Jonathan R Terman
Journal:  Nature       Date:  2010-02-11       Impact factor: 49.962

Review 5.  Multifunctional Abl kinases in health and disease.

Authors:  Aaditya Khatri; Jun Wang; Ann Marie Pendergast
Journal:  J Cell Sci       Date:  2016-01-01       Impact factor: 5.285

6.  Amplification of F-Actin Disassembly and Cellular Repulsion by Growth Factor Signaling.

Authors:  Jimok Yoon; Sang Bum Kim; Giasuddin Ahmed; Jerry W Shay; Jonathan R Terman
Journal:  Dev Cell       Date:  2017-07-06       Impact factor: 12.270

Review 7.  Semaphorins and their Signaling Mechanisms.

Authors:  Laura Taylor Alto; Jonathan R Terman
Journal:  Methods Mol Biol       Date:  2017

Review 8.  Hallmarks of cancer: the next generation.

Authors:  Douglas Hanahan; Robert A Weinberg
Journal:  Cell       Date:  2011-03-04       Impact factor: 41.582

9.  SelR reverses Mical-mediated oxidation of actin to regulate F-actin dynamics.

Authors:  Ruei-Jiun Hung; Christopher S Spaeth; Hunkar Gizem Yesilyurt; Jonathan R Terman
Journal:  Nat Cell Biol       Date:  2013-11-10       Impact factor: 28.824

10.  F-actin dismantling through a redox-driven synergy between Mical and cofilin.

Authors:  Elena E Grintsevich; Hunkar Gizem Yesilyurt; Shannon K Rich; Ruei-Jiun Hung; Jonathan R Terman; Emil Reisler
Journal:  Nat Cell Biol       Date:  2016-07-25       Impact factor: 28.824
  10 in total
  7 in total

1.  Human MICAL1: Activation by the small GTPase Rab8 and small-angle X-ray scattering studies on the oligomerization state of MICAL1 and its complex with Rab8.

Authors:  Alessandro Esposito; Valeria Ventura; Maxim V Petoukhov; Amrita Rai; Dmitri I Svergun; Maria A Vanoni
Journal:  Protein Sci       Date:  2018-10-31       Impact factor: 6.725

Review 2.  Structural Characteristics, Binding Partners and Related Diseases of the Calponin Homology (CH) Domain.

Authors:  Lei-Miao Yin; Michael Schnoor; Chang-Duk Jun
Journal:  Front Cell Dev Biol       Date:  2020-05-14

3.  NEDD9 Facilitates Hypoxia-Induced Gastric Cancer Cell Migration via MICAL1 Related Rac1 Activation.

Authors:  Shuo Zhao; Pengxiang Min; Lei Liu; Lin Zhang; Yujie Zhang; Yueyuan Wang; Xuyang Zhao; Yadong Ma; Hui Xie; Chenchen Zhu; Haonan Jiang; Jun Du; Luo Gu
Journal:  Front Pharmacol       Date:  2019-04-04       Impact factor: 5.810

4.  MICAL2 Facilitates Gastric Cancer Cell Migration via MRTF-A-Mediated CDC42 Activation.

Authors:  Yueyuan Wang; Pengxiang Min; Chenxiang Qi; Shuo Zhao; Minjie Yu; Yujie Zhang; Jun Du
Journal:  Front Mol Biosci       Date:  2021-03-24

5.  High MICAL-L2 expression and its role in the prognosis of colon adenocarcinoma.

Authors:  Yixing Yang; Fengwen Ye; Tianxiang Xia; Qianwen Wang; Yujie Zhang; Jun Du
Journal:  BMC Cancer       Date:  2022-05-02       Impact factor: 4.638

6.  MICAL2 contributes to gastric cancer cell migration via Cdc42-dependent activation of E-cadherin/β-catenin signaling pathway.

Authors:  Qianwen Wang; Chenxiang Qi; Pengxiang Min; Yueyuan Wang; Fengwen Ye; Tianxiang Xia; Yujie Zhang; Jun Du
Journal:  Cell Commun Signal       Date:  2022-09-05       Impact factor: 7.525

Review 7.  Actin Mutations and Their Role in Disease.

Authors:  Francine Parker; Thomas G Baboolal; Michelle Peckham
Journal:  Int J Mol Sci       Date:  2020-05-10       Impact factor: 6.208
  7 in total

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