Literature DB >> 29404386

Bcl-2 proteins: Unraveling the details of a complex and dynamic network.

Stephanie Bleicken1,2, Ana J Garcia-Saez1,2.   

Abstract

Apoptosis regulation by Bcl-2 proteins is pivotal for mammalians, not only because it is key for development but also because aberrant apoptosis is prerequisite to severe diseases, like cancer. Recently, we quantified interactions within the Bcl-2 protein network in solution and membranes, and addressed membrane recruitment, preference of interaction partners and the consequences for Bax activation and inhibition.

Entities:  

Keywords:  Bcl-2 proteins; mitochondrial apoptosis

Year:  2017        PMID： 29404386      PMCID： PMC5791859          DOI： 10.1080/23723556.2017.1384880

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  11 in total

1.  Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax.

Authors:  Jonathan F Lovell; Lieven P Billen; Scott Bindner; Aisha Shamas-Din; Cecile Fradin; Brian Leber; David W Andrews
Journal:  Cell       Date:  2008-12-12       Impact factor: 41.582

2.  Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol.

Authors:  Frank Edlich; Soojay Banerjee; Motoshi Suzuki; Megan M Cleland; Damien Arnoult; Chunxin Wang; Albert Neutzner; Nico Tjandra; Richard J Youle
Journal:  Cell       Date:  2011-04-01       Impact factor: 41.582

3.  A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection.

Authors:  Xin Niu; Hetal Brahmbhatt; Philipp Mergenthaler; Zhi Zhang; Jing Sang; Michael Daude; Fabian G R Ehlert; Wibke E Diederich; Eve Wong; Weijia Zhu; Justin Pogmore; Jyoti P Nandy; Maragani Satyanarayana; Ravi K Jimmidi; Prabhat Arya; Brian Leber; Jialing Lin; Carsten Culmsee; Jing Yi; David W Andrews
Journal:  Cell Chem Biol       Date:  2017-04-06       Impact factor: 8.116

4.  Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation.

Authors:  Stephanie Bleicken; Annika Hantusch; Kushal Kumar Das; Tancred Frickey; Ana J Garcia-Saez
Journal:  Nat Commun       Date:  2017-07-13       Impact factor: 14.919

5.  Systems analysis of BCL2 protein family interactions establishes a model to predict responses to chemotherapy.

Authors:  Andreas U Lindner; Caoimhín G Concannon; Gerhardt J Boukes; Mary D Cannon; Fabien Llambi; Deborah Ryan; Karen Boland; Joan Kehoe; Deborah A McNamara; Frank Murray; Elaine W Kay; Suzanne Hector; Douglas R Green; Heinrich J Huber; Jochen H M Prehn
Journal:  Cancer Res       Date:  2013-01-15       Impact factor: 12.701

6.  Proapoptotic Bax and Bak proteins form stable protein-permeable pores of tunable size.

Authors:  Stephanie Bleicken; Olatz Landeta; Ane Landajuela; Gorka Basañez; Ana J García-Sáez
Journal:  J Biol Chem       Date:  2013-10-07       Impact factor: 5.157

7.  Bax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric species.

Authors:  Yamunadevi Subburaj; Katia Cosentino; Markus Axmann; Esteban Pedrueza-Villalmanzo; Eduard Hermann; Stephanie Bleicken; Joachim Spatz; Ana J García-Sáez
Journal:  Nat Commun       Date:  2015-08-14       Impact factor: 14.919

8.  cBid, Bax and Bcl-xL exhibit opposite membrane remodeling activities.

Authors:  S Bleicken; G Hofhaus; B Ugarte-Uribe; R Schröder; A J García-Sáez
Journal:  Cell Death Dis       Date:  2016-02-25       Impact factor: 8.469

9.  Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane.

Authors:  Katelyn L O'Neill; Kai Huang; Jingjing Zhang; Yi Chen; Xu Luo
Journal:  Genes Dev       Date:  2016-04-07       Impact factor: 11.361

10.  Bax exists in a dynamic equilibrium between the cytosol and mitochondria to control apoptotic priming.

Authors:  Barbara Schellenberg; Pengbo Wang; James A Keeble; Ricardo Rodriguez-Enriquez; Scott Walker; Thomas W Owens; Fiona Foster; Jolanta Tanianis-Hughes; Keith Brennan; Charles H Streuli; Andrew P Gilmore
Journal:  Mol Cell       Date:  2013-01-31       Impact factor: 17.970
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  1 in total

1.  Topology of active, membrane-embedded Bax in the context of a toroidal pore.

Authors:  Stephanie Bleicken; Tufa E Assafa; Carolin Stegmueller; Alice Wittig; Ana J Garcia-Saez; Enrica Bordignon
Journal:  Cell Death Differ       Date:  2018-09-05       Impact factor: 15.828
  1 in total

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