Literature DB >> 2940329

General method for the isolation of conditional lethal mutants in any required region of the virus genome: its application to the 'semi-essential' region of phage Mu.

L Paolozzi, P Ghelardini.   

Abstract

A general method is presented that enables viral mutants to be isolated in any required region of their genome. An application of the method is reported relating to the isolation of conditional lethal mutants in the "semi-essential' region of phage Mu. Some properties are described of one mutant found in this way, Mucts62SEEam8 Apl, which is typical of a class of mutants that were isolated.

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Year:  1986        PMID： 2940329     DOI： 10.1099/00221287-132-1-79

Source DB:  PubMed          Journal:  J Gen Microbiol        ISSN： 0022-1287


  2 in total

Review 1.  The Mu gem operon: its role in gene expression, recombination and cell cycle.

Authors:  P Ghelardini; R La Valle; L Paolozzi
Journal:  Genetica       Date:  1994       Impact factor: 1.082

2.  Suppression of the thermosensitive DNA ligase mutations in Escherichia coli K12 through modulation of gene expression induced by phage Mu.

Authors:  P Ghelardini; J C Liebart; L Paolozzi; A M Pedrini
Journal:  Mol Gen Genet       Date:  1989-03
  2 in total

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