Lingmin Hu1,2, Yue Zhang3, Xing Wang2, Lianghui You2, Pengfei Xu2, Xianwei Cui2, Lijun Zhu2, Chenbo Ji2, Xirong Guo2, Juan Wen2. 1. The Affiliated Changzhou Maternity and Child Health Care Hospital of Nanjing Medical University, Changzhou, China. 2. Nanjing Maternity and Child Health Care Institute, Nanjing Maternity and Child Health Care Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, China. 3. School of Information Management, Nanjing University, Nanjing, China.
Abstract
BACKGROUND/AIMS: Whether maternal vitamin D deficiency is associated with gestational diabetes remains controversial. This meta-analysis aimed to systematically evaluate published evidence on the association between maternal vitamin D status and the risk of gestational diabetes. METHODS: We retrieved relevant articles from the PubMed, Medline and Embase databases up to May 2017 for observational studies investigating the association between vitamin D status and the risk of gestational diabetes. Odds ratios (OR) or risk ratios (RR) from individual studies were pooled using the fixed and random effect models. RESULTS: The meta-analysis of 29 observational studies included 28,982 participants, of which 4,634 were diagnosed with gestational diabetes, and showed that maternal vitamin D insufficiency was associated with a significantly increased risk of gestational diabetes by 39% (pooled OR = 1.39, 95%CI = 1.20-1.60) with moderate heterogeneity (I2 = 50.2%; P = 0.001). Moreover, the 25(OH)D level was significantly lower in gestational diabetes cases than in controls with a pooled effect of -4.79 nmol/L (95% CI = -6.43, -3.15). Significant heterogeneity was also detected (I2 = 65.0%, P < 0.001). Further subgroup analysis indicated that this association was also evident in most subpopulations. CONCLUSION: This meta-analysis indicated a significant association between vitamin D insufficiency and increased risk of gestational diabetes. Further well-designed large-scale clinical trials are essential to verify this association.
BACKGROUND/AIMS: Whether maternal vitamin D deficiency is associated with gestational diabetes remains controversial. This meta-analysis aimed to systematically evaluate published evidence on the association between maternal vitamin D status and the risk of gestational diabetes. METHODS: We retrieved relevant articles from the PubMed, Medline and Embase databases up to May 2017 for observational studies investigating the association between vitamin D status and the risk of gestational diabetes. Odds ratios (OR) or risk ratios (RR) from individual studies were pooled using the fixed and random effect models. RESULTS: The meta-analysis of 29 observational studies included 28,982 participants, of which 4,634 were diagnosed with gestational diabetes, and showed that maternal vitamin Dinsufficiency was associated with a significantly increased risk of gestational diabetes by 39% (pooled OR = 1.39, 95%CI = 1.20-1.60) with moderate heterogeneity (I2 = 50.2%; P = 0.001). Moreover, the 25(OH)D level was significantly lower in gestational diabetes cases than in controls with a pooled effect of -4.79 nmol/L (95% CI = -6.43, -3.15). Significant heterogeneity was also detected (I2 = 65.0%, P < 0.001). Further subgroup analysis indicated that this association was also evident in most subpopulations. CONCLUSION: This meta-analysis indicated a significant association between vitamin Dinsufficiency and increased risk of gestational diabetes. Further well-designed large-scale clinical trials are essential to verify this association.
Authors: John Mechenro; Giriprasad Venugopal; M Buvnesh Kumar; D Balakrishnan; Balakrishnan S Ramakrishna Journal: BMC Public Health Date: 2018-12-05 Impact factor: 3.295
Authors: Pratibha Dwarkanath; Ponnusamy Vinotha; Tinku Thomas; Siji Joseph; Annamma Thomas; George Shirley; C N Sheela; Saurabh Mehta; Anura V Kurpad Journal: Front Nutr Date: 2019-08-06