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Literature DB >> 29402738

Potentiation of the activity of β-lactam antibiotics by farnesol and its derivatives.

Choon Kim¹, Dusan Hesek¹, Mijoon Lee¹, Shahriar Mobashery².

Abstract

Farnesol, a sesquiterpene alcohol, potentiates the activity of β-lactam antibiotics against antibiotic-resistant bacteria. We document that farnesol and two synthetic derivatives (compounds 2 and 6) have poor antibacterial activities of their own, but they potentiate the activities of ampicillin and oxacillin against Staphylococcus aureus strains (including methicillin-resistant S. aureus). These compounds attenuate the rate of growth of bacteria, which has to be taken into account in assessment of the potentiation effect.

Entities: Chemical Species

Keywords: Antimicrobial activity; Farnesol; Methicillin-resistant Staphylococcus aureus (MRSA); Potentiation; β-Lactam antibiotics

Mesh：

Substances：

Year: 2018 PMID： 29402738 PMCID： PMC5817034 DOI： 10.1016/j.bmcl.2018.01.028

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

13 in total

1. Synergy, antagonism, and what the chequerboard puts between them.

Authors: F C Odds
Journal: J Antimicrob Chemother Date: 2003-06-12 Impact factor: 5.790

2. The antibacterial effects of terpene alcohols on Staphylococcus aureus and their mode of action.

Authors: Yoshihiro Inoue; Akiko Shiraishi; Toshiko Hada; Kazuma Hirose; Hajime Hamashima; Jingoro Shimada
Journal: FEMS Microbiol Lett Date: 2004-08-15 Impact factor: 2.742

3. Effect of farnesol on Candida dubliniensis biofilm formation and fluconazole resistance.

Authors: Mary Ann Jabra-Rizk; Mark Shirtliff; Cathy James; Timothy Meiller
Journal: FEMS Yeast Res Date: 2006-11 Impact factor: 2.796

4. Sesquiterpene farnesol inhibits recycling of the C55 lipid carrier of the murein monomer precursor contributing to increased susceptibility to beta-lactams in methicillin-resistant Staphylococcus aureus.

Authors: Makoto Kuroda; Sanae Nagasaki; Toshiko Ohta
Journal: J Antimicrob Chemother Date: 2007-01-22 Impact factor: 5.790

5. Effect of farnesol on Staphylococcus aureus biofilm formation and antimicrobial susceptibility.

Authors: M A Jabra-Rizk; T F Meiller; C E James; M E Shirtliff
Journal: Antimicrob Agents Chemother Date: 2006-04 Impact factor: 5.191

6. The fractional inhibitory concentration (FIC) index as a measure of synergy.

Authors: M J Hall; R F Middleton; D Westmacott
Journal: J Antimicrob Chemother Date: 1983-05 Impact factor: 5.790

7. Farnesol-Induced Disruption of the Staphylococcus aureus Cytoplasmic Membrane.

Authors: Yoshihiro Inoue; Naoko Togashi; Hajime Hamashima
Journal: Biol Pharm Bull Date: 2016 Impact factor: 2.233

8. Sesquiterpene farnesol contributes to increased susceptibility to β-lactams in strains of Burkholderia pseudomallei.

Authors: R S N Brilhante; L G A Valente; M F G Rocha; T J P G Bandeira; R A Cordeiro; R A C Lima; J J G Leite; J F Ribeiro; J F Pereira; D S C M Castelo-Branco; A J Monteiro; J J C Sidrim
Journal: Antimicrob Agents Chemother Date: 2012-01-30 Impact factor: 5.191