Vsevolod V Kuzkov1, Maxim Y Obraztsov2, Oleg Y Ivashchenko3, Nadezhda Y Ivashchenko4, Valery M Gorenkov5, Mikhail Y Kirov3. 1. Department of Anesthesiology and Intensive Care Medicine, Northern State Medical University, Arkhangelsk, Russian Federation; Department of Anesthesiology and Intensive Care, City Hospital #1, Arkhangelsk, Russian Federation. Electronic address: v_kuzkov@mail.ru. 2. Department of Anesthesiology and Intensive Care, City Hospital #1, Arkhangelsk, Russian Federation. 3. Department of Anesthesiology and Intensive Care Medicine, Northern State Medical University, Arkhangelsk, Russian Federation; Department of Anesthesiology and Intensive Care, City Hospital #1, Arkhangelsk, Russian Federation. 4. Department of Anesthesiology and Intensive Care Medicine, Northern State Medical University, Arkhangelsk, Russian Federation. 5. Department of Vascular Surgery, City Hospital #1, Arkhangelsk, Russian Federation.
Abstract
OBJECTIVE:Carotid endarterectomy (CEA) is effective for the prevention of stroke, yet can be associated with a postoperative cognitive dysfunction (POCD) that may be affected by the type of anesthesia. The aim of the study was to compare the effects of total intravenous anesthesia (TIVA) with propofol to volatile induction and maintenance of anesthesia (VIMA) with sevoflurane on cerebral tissue oxygen saturation (SctO2) and POCD. DESIGN: Single-center, pilot randomized prospective study. SETTINGS: Single-center, 1,000-bed clinical hospital. PARTICIPANTS: The study included 40 adult male patients. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Patients were randomized to the TIVA (n = 20) or the VIMA (n = 20) groups. Cardiorespiratory parameters and SctO2 were monitored during CEA and through 20 hours postoperatively. Cognitive functions were assessed preoperatively and on days 1 and 5 after CEA using the Montreal Cognitive Assessment Score (MoCA). In both groups, the ipsilateral SctO2 decreased after clamping, whereas the contralateral SctO2 asymmetrically decreased in the TIVA group only compared both with baseline and with the VIMA group. The changes in MoCA by day 1 correlated with the relative change in the ipsilateral SctO2 after the clamping in the TIVA group (ρ = 0.54, p = 0.015). The improvement of MoCA from days 1 to 5 was related to the relative decline in MAP after the clamping. Better cognitive function was observed by day 5 after sevofluraneVIMA compared with TIVA. CONCLUSION: In CEA, VIMA with sevoflurane might preserve oxygenation in the contralateral hemisphere, suppress an asymmetry of cerebral oxygenation, and improve the early postoperative cognition compared with propofol anesthesia.
RCT Entities:
OBJECTIVE: Carotid endarterectomy (CEA) is effective for the prevention of stroke, yet can be associated with a postoperative cognitive dysfunction (POCD) that may be affected by the type of anesthesia. The aim of the study was to compare the effects of total intravenous anesthesia (TIVA) with propofol to volatile induction and maintenance of anesthesia (VIMA) with sevoflurane on cerebral tissue oxygen saturation (SctO2) and POCD. DESIGN: Single-center, pilot randomized prospective study. SETTINGS: Single-center, 1,000-bed clinical hospital. PARTICIPANTS: The study included 40 adult male patients. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS:Patients were randomized to the TIVA (n = 20) or the VIMA (n = 20) groups. Cardiorespiratory parameters and SctO2 were monitored during CEA and through 20 hours postoperatively. Cognitive functions were assessed preoperatively and on days 1 and 5 after CEA using the Montreal Cognitive Assessment Score (MoCA). In both groups, the ipsilateral SctO2 decreased after clamping, whereas the contralateral SctO2 asymmetrically decreased in the TIVA group only compared both with baseline and with the VIMA group. The changes in MoCA by day 1 correlated with the relative change in the ipsilateral SctO2 after the clamping in the TIVA group (ρ = 0.54, p = 0.015). The improvement of MoCA from days 1 to 5 was related to the relative decline in MAP after the clamping. Better cognitive function was observed by day 5 after sevoflurane VIMA compared with TIVA. CONCLUSION: In CEA, VIMA with sevoflurane might preserve oxygenation in the contralateral hemisphere, suppress an asymmetry of cerebral oxygenation, and improve the early postoperative cognition compared with propofol anesthesia.
Authors: Dana Raub; Katharina Platzbecker; Stephanie D Grabitz; Xinling Xu; Karuna Wongtangman; Stephanie B Pham; Kadhiresan R Murugappan; Khalid A Hanafy; Ala Nozari; Timothy T Houle; Samir M Kendale; Matthias Eikermann Journal: J Am Heart Assoc Date: 2021-02-26 Impact factor: 5.501