Marie Zöga Diederichsen1, Søren Zöga Diederichsen2, Hans Mickley3, Flemming Hald Steffensen4, Jess Lambrechtsen5, Niels Peter Rønnow Sand6, Kent Lodberg Christensen7, Michael Hecht Olsen8, Axel Diederichsen9, Mette Hjortdal Grønhøj3. 1. Department of Cardiology, Odense University Hospital, J.B. Winsløws Vej 4, DK-5000 Odense C, Denmark. Electronic address: mzdiederichsen@gmail.com. 2. Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej i, DK-2100 Copenhagen, Denmark. 3. Department of Cardiology, Odense University Hospital, J.B. Winsløws Vej 4, DK-5000 Odense C, Denmark. 4. Department of Cardiology, Sygehus Lillebælt Vejle, Kabbeltoft 25, DK-7100 Vejle, Denmark. 5. Department of Cardiology, Svendborg Hospital, Valdemarsgade 53, DK-5700 Svendborg, Denmark. 6. Department of Cardiology, Hospital of South West Denmark, Finsensgade 35, DK-6700 Esbjerg, Denmark; Institute of Regional Health Services Research, University of Southern Denmark, Winsløwparken 19, c., DK-5000 Odense C, Denmark. 7. Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark. 8. Cardiology Section, Department of Internal Medicine, Holbæk Hospital, Smedelundsgade 60, DK-4300 Holbæk, Denmark; Centre for Individualized Medicine in Arterial Diseases (CIMA), Odense University Hospital, J.B. Winsløws Vej 4, DK-5000 Odense C, Denmark; Cardiovascular Centre of Excellence (CAVAC), University of Southern Denmark, Denmark. 9. Department of Cardiology, Odense University Hospital, J.B. Winsløws Vej 4, DK-5000 Odense C, Denmark; Centre for Individualized Medicine in Arterial Diseases (CIMA), Odense University Hospital, J.B. Winsløws Vej 4, DK-5000 Odense C, Denmark; Cardiovascular Centre of Excellence (CAVAC), University of Southern Denmark, Denmark.
Abstract
BACKGROUND AND AIMS: Studies have shown that soluble urokinase Plasminogen Activator Receptor (suPAR) and CRP (both inflammatory markers) and coronary artery calcification (CAC) are independent risk predictors for cardiovascular (CV) disease. The aim of this study is to assess whether suPAR and CRP have an increased predictive prognostic value beyond the traditional CV risk factors and the CAC score. METHODS: A population sample of 1179 subjects, free of CV disease was included. The subjects underwent traditional CV risk evaluation, CAC assessment and blood sampling for suPAR and CRP. CV events were extracted from The Danish National Patient Register after 6.5 years. The additive values of suPAR and CRP were evaluated by unadjusted Kaplan Meier analysis, adjusted hazard ratio and ROCAUC models. RESULTS: 1179 participants (47.6% males, mean age 55 years) were included. 73 events occurred. In Kaplan Meier analyses, suPAR and CRP were significantly associated with CV events (p = 0.03 and p = 0.002). Adjusted for the CV risk factors and the CAC score, the hazard ratios for suPAR and CRP were 1.17 (95% confidence interval [CI] 1.01-1.34) and 1.04 (95% CI 1.01-1.06), respectively. suPAR was associated with a substantial risk among women (2.03; 95% CI 1.45-2.84) and 60-year-old subjects (1.44; 95% CI 1.09-1.90). By ROCAUC, neither suPAR nor CRP provided significant estimates (0.7100 and 0.7054) compared to the traditionally CV risk factors (0.6952, p = 0.24 and p = 0.16) and CAC score (0.7481, p = 0.33 and p = 0.32). CONCLUSIONS: Adjusted for traditional CV risk factors and CAC score, suPAR and CRP were of minor importance in risk prediction.
BACKGROUND AND AIMS: Studies have shown that soluble urokinase Plasminogen Activator Receptor (suPAR) and CRP (both inflammatory markers) and coronary artery calcification (CAC) are independent risk predictors for cardiovascular (CV) disease. The aim of this study is to assess whether suPAR and CRP have an increased predictive prognostic value beyond the traditional CV risk factors and the CAC score. METHODS: A population sample of 1179 subjects, free of CV disease was included. The subjects underwent traditional CV risk evaluation, CAC assessment and blood sampling for suPAR and CRP. CV events were extracted from The Danish National Patient Register after 6.5 years. The additive values of suPAR and CRP were evaluated by unadjusted Kaplan Meier analysis, adjusted hazard ratio and ROCAUC models. RESULTS: 1179 participants (47.6% males, mean age 55 years) were included. 73 events occurred. In Kaplan Meier analyses, suPAR and CRP were significantly associated with CV events (p = 0.03 and p = 0.002). Adjusted for the CV risk factors and the CAC score, the hazard ratios for suPAR and CRP were 1.17 (95% confidence interval [CI] 1.01-1.34) and 1.04 (95% CI 1.01-1.06), respectively. suPAR was associated with a substantial risk among women (2.03; 95% CI 1.45-2.84) and 60-year-old subjects (1.44; 95% CI 1.09-1.90). By ROCAUC, neither suPAR nor CRP provided significant estimates (0.7100 and 0.7054) compared to the traditionally CV risk factors (0.6952, p = 0.24 and p = 0.16) and CAC score (0.7481, p = 0.33 and p = 0.32). CONCLUSIONS: Adjusted for traditional CV risk factors and CAC score, suPAR and CRP were of minor importance in risk prediction.
Authors: Reidun Aarsetøy; Thor Ueland; Pål Aukrust; Annika E Michelsen; Ricardo Leon de la Fuente; Heidi Grundt; Harry Staines; Ottar Nygaard; Dennis W T Nilsen Journal: BMC Cardiovasc Disord Date: 2021-10-14 Impact factor: 2.298