Parisa Montazeri1,2,3, Martine Vrijheid1,2,3, David Martinez1,2,3, Mikel Basterrechea3,4,5, Ana Fernandez-Somoano3,6, Monica Guxens1,2,3, Carmen Iñiguez3,7, Aitana Lertxundi3,4,5, Mario Murcia3,7, Adonina Tardon3,6, Jordi Sunyer1,2,3, Damaskini Valvi1,2,3,8. 1. ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain. 2. Department of Experimental and Health Sciences, Pompeu Fabra University, Barcelona, Spain. 3. Center for Biomedical Research in the Network of Epidemiology and Public Health, Madrid, Spain. 4. Public Health Division of Gipuzkoa, Basque Government, San Sebastián, Spain. 5. Biodonostia Health Research Institute, San Sebastián, Spain. 6. University Institute of Oncology of the Principality of Asturias and Area of Preventive Medicine and Public Health, Department of Medicine, University of Oviedo, Oviedo, Asturias, Spain. 7. Epidemiology and Environmental Health Joint Research Unit, Foundation for the Promotion of Health and Biomedical Research of the Valencia Region, Jaume I University, and University of Valencia, Valencia, Spain. 8. Department of Environmental Health, T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.
Abstract
OBJECTIVE: The objective of this study was to evaluate the associations between maternal metabolic parameters and early childhood BMI trajectories. METHODS: Two thousand two hundred fifty-one children born in Spain between 2004 and 2008 were analyzed. Five BMI z score trajectories from birth to age 4 years were identified by using latent class growth analysis. Multinomial regression assessed the associations between maternal metabolic parameters and offspring's BMI trajectories. RESULTS: Children in the reference BMI trajectory had average size at birth followed by a slower BMI gain. Maternal prepregnancy obesity was associated with trajectories of accelerated BMI gain departing from either higher (relative risk ratio [RRR] = 1.77; 95% CI: 1.07-2.91) or lower size at birth (RRR = 1.91; 95% CI: 1.17-3.12). Gestational weight gain (GWG) above clinical guidelines was associated with a trajectory of higher birth size followed by accelerated BMI gain (RRR = 2.14; 95% CI: 1.53-2.97). Maternal serum triglycerides were negatively associated with BMI trajectories departing from lower birth sizes. Gestational diabetes, maternal serum cholesterol, and C-reactive protein were unrelated to children's BMI trajectories. CONCLUSIONS: Maternal prepregnancy obesity, GWG, and serum triglycerides are associated with longitudinal BMI trajectories in early childhood that may increase disease risk in later life. Health initiatives should promote healthy weight status before and during pregnancy to improve maternal and child health.
OBJECTIVE: The objective of this study was to evaluate the associations between maternal metabolic parameters and early childhood BMI trajectories. METHODS: Two thousand two hundred fifty-one children born in Spain between 2004 and 2008 were analyzed. Five BMI z score trajectories from birth to age 4 years were identified by using latent class growth analysis. Multinomial regression assessed the associations between maternal metabolic parameters and offspring's BMI trajectories. RESULTS:Children in the reference BMI trajectory had average size at birth followed by a slower BMI gain. Maternal prepregnancy obesity was associated with trajectories of accelerated BMI gain departing from either higher (relative risk ratio [RRR] = 1.77; 95% CI: 1.07-2.91) or lower size at birth (RRR = 1.91; 95% CI: 1.17-3.12). Gestational weight gain (GWG) above clinical guidelines was associated with a trajectory of higher birth size followed by accelerated BMI gain (RRR = 2.14; 95% CI: 1.53-2.97). Maternal serum triglycerides were negatively associated with BMI trajectories departing from lower birth sizes. Gestational diabetes, maternal serum cholesterol, and C-reactive protein were unrelated to children's BMI trajectories. CONCLUSIONS:Maternal prepregnancy obesity, GWG, and serum triglycerides are associated with longitudinal BMI trajectories in early childhood that may increase disease risk in later life. Health initiatives should promote healthy weight status before and during pregnancy to improve maternal and child health.
Authors: William Campodonico-Burnett; Byron Hetrick; Stephanie R Wesolowski; Simon Schenk; Diana L Takahashi; Tyler A Dean; Elinor L Sullivan; Paul Kievit; Maureen Gannon; Kjersti Aagaard; Jacob E Friedman; Carrie E McCurdy Journal: Diabetes Date: 2020-04-30 Impact factor: 9.461
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