Literature DB >> 29399933

Loganic Acid Methyltransferase: Insights into the Specificity of Methylation on an Iridoid Glycoside.

Nektaria Petronikolou1,2, Allison J Hollatz3, Mary A Schuler1,4, Satish K Nair1,2,5.   

Abstract

Loganin is an iridoid glycoside of interest as both an intermediate in the biosynthesis of indole alkaloids in plants and as a bioactive compound itself. Loganic acid methyltransferase catalyzes the methylation of a monoterpenoid glycoside precursor to produce loganin and demonstrates stereospecificity for the (6S,7R) substrate. We have biochemically characterized this biocatalyst and elucidated the basis for its strict substrate specificity. These studies could help facilitate the design of new classes of monoterpenoid indole alkaloids of pharmaceutical interest.
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  iridoid; loganin; methyltransferase; monoterpenoid indole alkaloids

Mesh：

Substances：

Year:  2018        PMID： 29399933     DOI： 10.1002/cbic.201700679

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


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