| Literature DB >> 29398123 |
Jay P Ross1, Sadaf Mohtashami2, Etienne Leveille3, Amelie M Johnson4, Lan Xiong5, Patrick A Dion6, Edward Fon2, Yves Dauvilliers7, Nicolas Dupré8, Guy A Rouleau9, Ziv Gan-Or10.
Abstract
A recent genome-wide association study identified variants associated with essential tremor (ET). The present study aimed to examine potential genetic overlap between ET and Parkinson's disease (PD). The top 22 variants identified by the ET genome-wide association study and 4 additional variants from previous studies were genotyped in a cohort of French and French-Canadian PD patients (n = 717) and controls (n = 595). Logistic regression analysis, adjusted for age and sex, was used to test for association between genotype and PD. None of the variants tested in the present study was significantly associated with PD. Our results do not support a role of ET-associated genetic variants in PD.Entities:
Keywords: Essential tremor; GWAS; Parkinson's disease
Mesh：
Year: 2018 PMID： 29398123 DOI： 10.1016/j.neurobiolaging.2018.01.001
Source DB: PubMed Journal: Neurobiol Aging ISSN： 0197-4580 Impact factor: 4.673