| Literature DB >> 29397774 |
Li-Li Lou1, Peng Zhao1, Zhuo-Yang Cheng1, Rui Guo1, Guo-Dong Yao1, Xiao-Bo Wang2, Xiao-Xiao Huang1,2, Shao-Jiang Song1.
Abstract
In this study, a new coumarin, juglansoside C (1) was isolated from the bark of Juglans mandshurica. Its chemical structure was identified by comprehensive spectroscopic analyses. The in vitro cytotoxicity assay showed that 1 exhibited moderate cytotoxicity against human hepatocellular carcinoma Hep3B cells with an IC50 value of 70.9 μM. Furthermore, Annexin V-FITC/PI staining assay indicated that 1 markedly induced apoptosis in Hep3B cells.Entities:
Keywords: apoptosis; coumarin; cytotoxicity; hepatocellular carcinoma
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Year: 2018 PMID： 29397774 DOI： 10.1080/14786419.2018.1434646
Source DB: PubMed Journal: Nat Prod Res ISSN： 1478-6419 Impact factor: 2.861