Literature DB >> 29397533

Estrogen Receptors Are Involved in the Neuroprotective Effect of Silibinin in Aβ1-42-Treated Rats.

Xiaoyu Song1,2, Bo Liu1, Lingyu Cui1, Biao Zhou1, Lu Liu1, Weiwei Liu1, Guodong Yao1,3, Mingyu Xia1, Toshihiko Hayashi1, Shunji Hattori4, Yuko Ushiki-Kaku4, Shin-Ichi Tashiro5, Takashi Ikejima6.   

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease that is characterized by a cascade of pathologic changes. A widely discussed theory indicates that amyloid β (Aβ) peptides are the causative agents of AD. Silibinin, a flavonoid derived from milk thistle, is well known for its hepato-protective activities and we have reported the neuroprotective effects of silibinin. In this study, we investigated the role of estrogen receptors (ERs) in silibinin's neuroprotective effect on Aβ1-42-injected rats. Results of Morris water maze and novel object-recognition tests demonstrated that silibinin significantly attenuated Aβ1-42-induced memory impairment. Silibinin attenuated ERs and PI3K-Akt pathways, as well as modulated mitogen-activated protein kinases in the hippocampus of Aβ1-42-injected rats. Taken together, silibinin is a potential candidate in the treatment of Alzheimer's disease.

Entities:  

Keywords:  Alzheimer’s disease; Amyloid; Estrogen receptor; Memory impairment; Silibinin

Mesh：

Substances：

Year:  2018        PMID： 29397533     DOI： 10.1007/s11064-018-2481-3

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  38 in total

1.  Intraneuronal Abeta42 accumulation in human brain.

Authors:  G K Gouras; J Tsai; J Naslund; B Vincent; M Edgar; F Checler; J P Greenfield; V Haroutunian; J D Buxbaum; H Xu; P Greengard; N R Relkin
Journal:  Am J Pathol       Date:  2000-01       Impact factor: 4.307

2.  Increased expression of estrogen receptor alpha and beta in the nucleus basalis of Meynert in Alzheimer's disease.

Authors:  T A Ishunina; D F Swaab
Journal:  Neurobiol Aging       Date:  2001 May-Jun       Impact factor: 4.673

Review 3.  A review of estrogen receptor alpha gene (ESR1) polymorphisms, mood, and cognition.

Authors:  Erin E Sundermann; Pauline M Maki; Jeffrey R Bishop
Journal:  Menopause       Date:  2010-07       Impact factor: 2.953

4.  Neuroprotective effect of silymarin in 6-hydroxydopamine hemi-parkinsonian rat: involvement of estrogen receptors and oxidative stress.

Authors:  Tourandokht Baluchnejadmojarad; Mehrdad Roghani; Mehdi Mafakheri
Journal:  Neurosci Lett       Date:  2010-06-18       Impact factor: 3.046

Review 5.  Mechanisms of estrogen action.

Authors:  S Nilsson; S Mäkelä; E Treuter; M Tujague; J Thomsen; G Andersson; E Enmark; K Pettersson; M Warner; J A Gustafsson
Journal:  Physiol Rev       Date:  2001-10       Impact factor: 37.312

6.  Ginsenoside Rg1 promotes nonamyloidgenic cleavage of APP via estrogen receptor signaling to MAPK/ERK and PI3K/Akt.

Authors:  Chun Shi; Dong-dan Zheng; Li Fang; Fengming Wu; Wing Hang Kwong; Jie Xu
Journal:  Biochim Biophys Acta       Date:  2011-12-11

7.  Silibinin inhibits acetylcholinesterase activity and amyloid β peptide aggregation: a dual-target drug for the treatment of Alzheimer's disease.

Authors:  Songwei Duan; Xiaoyin Guan; Runxuan Lin; Xincheng Liu; Ying Yan; Ruibang Lin; Tianqi Zhang; Xueman Chen; Jiaqi Huang; Xicui Sun; Qingqing Li; Shaoliang Fang; Jun Xu; Zhibin Yao; Huaiyu Gu
Journal:  Neurobiol Aging       Date:  2015-02-11       Impact factor: 4.673

8.  Nutritional flavonoids impact on nuclear and extranuclear estrogen receptor activities.

Authors:  Paola Galluzzo; Maria Marino
Journal:  Genes Nutr       Date:  2006-09       Impact factor: 5.523

9.  ERβ up-regulation was involved in silibinin-induced growth inhibition of human breast cancer MCF-7 cells.

Authors:  Nan Zheng; Lu Liu; Weiwei Liu; Ping Zhang; Huai Huang; Linghe Zang; Toshihiko Hayashi; Shin-ichi Tashiro; Satoshi Onodera; Mingyu Xia; Takashi Ikejima
Journal:  Arch Biochem Biophys       Date:  2016-01-06       Impact factor: 4.013

10.  Silibinin prevents amyloid beta peptide-induced memory impairment and oxidative stress in mice.

Authors:  P Lu; T Mamiya; L L Lu; A Mouri; Lb Zou; T Nagai; M Hiramatsu; T Ikejima; T Nabeshima
Journal:  Br J Pharmacol       Date:  2009-06-22       Impact factor: 8.739
View more
  5 in total

1.  Oral Administration of Silibinin Ameliorates Cognitive Deficits of Parkinson's Disease Mouse Model by Restoring Mitochondrial Disorders in Hippocampus.

Authors:  Xiumin Liu; Chenkang Wang; Weiwei Liu; Siaoyu Song; Jianing Fu; Toshihiko Hayashi; Kazunori Mizuno; Shunji Hattori; Hitomi Fujisaki; Takashi Ikejima
Journal:  Neurochem Res       Date:  2021-06-07       Impact factor: 3.996

2.  Crocin Improves Cognitive Behavior in Rats with Alzheimer's Disease by Regulating Endoplasmic Reticulum Stress and Apoptosis.

Authors:  Ling Lin; Guoliang Liu; Lina Yang
Journal:  Biomed Res Int       Date:  2019-08-26       Impact factor: 3.411

Review 3.  Mechanistic Insights into the Pharmacological Significance of Silymarin.

Authors:  Karan Wadhwa; Rakesh Pahwa; Manish Kumar; Shobhit Kumar; Prabodh Chander Sharma; Govind Singh; Ravinder Verma; Vineet Mittal; Inderbir Singh; Deepak Kaushik; Philippe Jeandet
Journal:  Molecules       Date:  2022-08-21       Impact factor: 4.927

Review 4.  Roles of traditional chinese medicine regulating neuroendocrinology on AD treatment.

Authors:  Chujun Deng; Huize Chen; Zeyu Meng; Shengxi Meng
Journal:  Front Endocrinol (Lausanne)       Date:  2022-09-21       Impact factor: 6.055

5.  Sex-Specific Cognitive Deficits Following Space Radiation Exposure.

Authors:  Vipan K Parihar; Maria C Angulo; Barrett D Allen; Amber Syage; Manal T Usmani; Estrella Passerat de la Chapelle; Amal Nayan Amin; Lidia Flores; Xiaomeng Lin; Erich Giedzinski; Charles L Limoli
Journal:  Front Behav Neurosci       Date:  2020-09-16       Impact factor: 3.558
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.