| Literature DB >> 29395717 |
Christophe Viret1, Aurore Rozières1, Mathias Faure2.
Abstract
NDP52/CALCOCO2 makes multiple contributions to selective autophagy. By interacting with cargos and LC3, NDP52 directs autophagy targets to autophagosomes. In addition, NDP52 promotes autophagosomes fusion with endolysosomes by connecting autophagosomes to MYOSIN VI. Recent studies reveal that Rab35 GTPase controls NDP52 recruitment to its targets and that NDP52 triggers MYOSIN VI (MYO6) motility.Entities:
Keywords: NDP52; autophagosome; autophagy receptor; maturation; myosin VI; selective autophagy
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Year: 2018 PMID: 29395717 DOI: 10.1016/j.tcb.2018.01.003
Source DB: PubMed Journal: Trends Cell Biol ISSN: 0962-8924 Impact factor: 20.808