Seung Wan Suh1, Ji Won Han1, Ju Ri Lee1, Seonjeong Byun1, Soon Jai Kwon1, Sang Hoon Oh1, Kyoung Hwan Lee1, Guehee Han1, Jong Woo Hong1, Kyung Phil Kwak2, Bong-Jo Kim3, Shin Gyeom Kim4, Jeong Lan Kim5, Tae Hui Kim6, Seung-Ho Ryu7, Seok Woo Moon8, Joon Hyuk Park9, Jiyeong Seo10, Jong Chul Youn11, Dong Young Lee12,13, Dong Woo Lee14, Seok Bum Lee15, Jung Jae Lee15, Jin Hyeong Jhoo16, Ki Woong Kim1,13,17,18. 1. Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam. 2. Department of Psychiatry, Dongguk University Gyeongju Hospital, Gyeongju. 3. Department of Psychiatry, Gyeongsang National University School of Medicine, Jinju. 4. Department of Neuropsychiatry, Soonchunhyang University Bucheon Hospital, Bucheon. 5. Department of Psychiatry, School of Medicine, Chungnam National University, Daejeon. 6. Department of Psychiatry, Yonsei University Wonju Severance Christian Hospital, Wonju. 7. Department of Psychiatry, School of Medicine, Konkuk University, Konkuk University Medical Center, Seoul. 8. Department of Psychiatry, School of Medicine, Konkuk University, Konkuk University Chungju Hospital, Chungju. 9. Department of Neuropsychiatry, Jeju National University Hospital, Jeju. 10. Department of Psychiatry, Gyeongsang National University Hospital, Jinju. 11. Department of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly, Yongin. 12. Department of Neuropsychiatry, Seoul National University Hospital, Seoul. 13. Department of Psychiatry, Seoul National University, College of Medicine, Seoul. 14. Department of Neuropsychiatry, Inje University Sanggye Paik Hospital, Seoul. 15. Department of Psychiatry, Dankook University Hospital, Cheonan. 16. Department of Psychiatry, Kangwon National University, School of Medicine, Chuncheon. 17. Department of Brain and Cognitive Sciences, Seoul National University, College of Natural Sciences, Seoul. 18. National Institute of Dementia, Seongnam, Korea.
Abstract
OBJECTIVE: To investigate sleep disturbances that induce cognitive changes over 4 years in nondemented elderlies. METHODS: Data were acquired from a nationwide, population-based, prospective cohort of Korean elderlies (2,238 normal cognition [NC] and 655 mild cognitive impairment [MCI]). At baseline and 4-year follow-up assessments, sleep-related parameters (midsleep time, sleep duration, sleep latency, subjective sleep quality, sleep efficiency, and daytime dysfunction) and cognitive status were measured using the Pittsburgh Sleep Quality Index and Consortium to Establish a Registry for Alzheimer's Disease Assessment, respectively. We used logistic regression models adjusted for covariates including age, sex, education, apolipoprotein E genotype, Geriatric Depression Scale, Cumulative Illness Rating Scale, and physical activity. RESULTS: In participants with NC, long sleep latency (>30 minutes), long sleep duration (≥7.95 hours), and late midsleep time (after 3:00 am) at baseline were related to the risk of cognitive decline at 4-year follow-up assessment; odds ratio (OR) was 1.40 for long sleep latency, 1.67 for long sleep duration, and 0.61 for late midsleep time. These relationships remained significant when these variables maintained their status throughout the follow-up period. Newly developed long sleep latency also doubled the risk of cognitive decline. In those with MCI, however, only long sleep latency reduced the chance of reversion to NC (OR = 0.69). INTERPRETATION: As early markers of cognitive decline, long sleep latency can be used for elderlies with NC or MCI, whereas long sleep duration and relatively early sleep time might be used for cognitively normal elderlies only. Ann Neurol 2018;83:472-482.
OBJECTIVE: To investigate sleep disturbances that induce cognitive changes over 4 years in nondemented elderlies. METHODS: Data were acquired from a nationwide, population-based, prospective cohort of Korean elderlies (2,238 normal cognition [NC] and 655 mild cognitive impairment [MCI]). At baseline and 4-year follow-up assessments, sleep-related parameters (midsleep time, sleep duration, sleep latency, subjective sleep quality, sleep efficiency, and daytime dysfunction) and cognitive status were measured using the Pittsburgh Sleep Quality Index and Consortium to Establish a Registry for Alzheimer's Disease Assessment, respectively. We used logistic regression models adjusted for covariates including age, sex, education, apolipoprotein E genotype, Geriatric Depression Scale, Cumulative Illness Rating Scale, and physical activity. RESULTS: In participants with NC, long sleep latency (>30 minutes), long sleep duration (≥7.95 hours), and late midsleep time (after 3:00 am) at baseline were related to the risk of cognitive decline at 4-year follow-up assessment; odds ratio (OR) was 1.40 for long sleep latency, 1.67 for long sleep duration, and 0.61 for late midsleep time. These relationships remained significant when these variables maintained their status throughout the follow-up period. Newly developed long sleep latency also doubled the risk of cognitive decline. In those with MCI, however, only long sleep latency reduced the chance of reversion to NC (OR = 0.69). INTERPRETATION: As early markers of cognitive decline, long sleep latency can be used for elderlies with NC or MCI, whereas long sleep duration and relatively early sleep time might be used for cognitively normal elderlies only. Ann Neurol 2018;83:472-482.
Authors: Alberto R Ramos; Wassim Tarraf; Benson Wu; Susan Redline; Jianwen Cai; Martha L Daviglus; Linda Gallo; Yasmin Mossavar-Rahmani; Krista M Perreira; Phyllis Zee; Donglin Zeng; Hector M Gonzalez Journal: Alzheimers Dement Date: 2020-01-06 Impact factor: 21.566
Authors: Emma L Anderson; Rebecca C Richmond; Samuel E Jones; Gibran Hemani; Kaitlin H Wade; Hassan S Dashti; Jacqueline M Lane; Heming Wang; Richa Saxena; Ben Brumpton; Roxanna Korologou-Linden; Jonas B Nielsen; Bjørn Olav Åsvold; Gonçalo Abecasis; Elizabeth Coulthard; Simon D Kyle; Robin N Beaumont; Jessica Tyrrell; Timothy M Frayling; Marcus R Munafò; Andrew R Wood; Yoav Ben-Shlomo; Laura D Howe; Deborah A Lawlor; Michael N Weedon; George Davey Smith Journal: Int J Epidemiol Date: 2021-07-09 Impact factor: 7.196