| Literature DB >> 29394467 |
Sung Bong Kim1, Yi Zhang2,3, Sang Min Won1, Amay J Bandodkar2,3, Yurina Sekine4, Yeguang Xue5,6, Jahyun Koo2,3, Sean W Harshman7, Jennifer A Martin7, Jeong Min Park8,9, Tyler R Ray2,3, Kaitlyn E Crawford1,10, Kyu-Tae Lee1, Jungil Choi2,3, Rhonda L Pitsch11, Claude C Grigsby7, Adam J Strang12, Yu-Yu Chen1, Shuai Xu13,14, Jeonghyun Kim15, Ahyeon Koh16, Jeong Sook Ha17, Yonggang Huang18,6, Seung Wook Kim17, John A Rogers2,3,6,19,20,21,22,23.
Abstract
This paper introduces super absorbent polymer valves and colorimetric sensing reagents as enabling components of soft, skin-mounted microfluidic devices designed to capture, store, and chemically analyze sweat released from eccrine glands. The valving technology enables robust means for guiding the flow of sweat from an inlet location into a collection of isolated reservoirs, in a well-defined sequence. Analysis in these reservoirs involves a color responsive indicator of chloride concentration with a formulation tailored to offer stable operation with sensitivity optimized for the relevant physiological range. Evaluations on human subjects with comparisons against ex situ analysis illustrate the practical utility of these advances.Entities:
Keywords: microfluidics; perspiration; super absorbent polymer; sweat chloride
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Year: 2018 PMID： 29394467 DOI： 10.1002/smll.201703334
Source DB: PubMed Journal: Small ISSN： 1613-6810 Impact factor: 13.281