Bum-Joo Cho1,2, Dong Yoon Kim3, Un Chul Park2, Joo Yong Lee3, Young Hee Yoon3, Hyeong Gon Yu2. 1. a Department of Ophthalmology , Hallym University College of Medicine, Chuncheon Sacred Heart Hospital , Chuncheon , Korea. 2. b Department of Ophthalmology , Seoul National University College of Medicine, Seoul National University Hospital , Seoul , Korea. 3. c Department of Ophthalmology , University of Ulsan, College of Medicine, Asan Medical Center , Seoul , Korea.
Abstract
PURPOSE: To compare the clinical features and treatment outcomes of different types of vitreoretinal lymphoma (VRL) that presents primarily, secondarily, or concurrently in association with CNS lymphoma. METHODS: We retrospectively reviewed the medical records of 53 patients with VRL pathologically confirmed between 2000 and 2014 in two of the largest tertiary hospitals in Korea. RESULTS: The proportions of primary, secondary, and concurrent VRL were 26%, 34%, and 40%, respectively. The primary VRL group had retinal infiltration most frequently (68%) among all groups and presented with the worst visual acuity at diagnosis (P = 0.035). The diagnostic delay was significantly shorter in patients with secondary VRL (1.4 months; P < 0.001). Median overall survival was 31 months in the entire cohort, and it was shortest in the concurrent VRL/CNS lymphoma group (18 months; P = 0.007). CONCLUSIONS: Ocular presentation and survival times may be different in VRL patients according to the association with CNS involvement.
PURPOSE: To compare the clinical features and treatment outcomes of different types of vitreoretinal lymphoma (VRL) that presents primarily, secondarily, or concurrently in association with CNS lymphoma. METHODS: We retrospectively reviewed the medical records of 53 patients with VRL pathologically confirmed between 2000 and 2014 in two of the largest tertiary hospitals in Korea. RESULTS: The proportions of primary, secondary, and concurrent VRL were 26%, 34%, and 40%, respectively. The primary VRL group had retinal infiltration most frequently (68%) among all groups and presented with the worst visual acuity at diagnosis (P = 0.035). The diagnostic delay was significantly shorter in patients with secondary VRL (1.4 months; P < 0.001). Median overall survival was 31 months in the entire cohort, and it was shortest in the concurrent VRL/CNS lymphoma group (18 months; P = 0.007). CONCLUSIONS: Ocular presentation and survival times may be different in VRL patients according to the association with CNS involvement.
Authors: Victor Llorenç; Carla Fuster; Carmen Alba-Linero; Aina Moll-Udina; Alba Serrano; Manel Solé; Maite Sainz de la Maza; Iban Aldecoa; Alfredo Adán Journal: J Ophthalmol Date: 2019-10-16 Impact factor: 1.909
Authors: Josephus L M van Rooij; Klaudia A Tokarska; Ninette H Ten Dam-van Loon; Peter H Wessels; Tatjana Seute; Monique C Minnema; Tom J Snijders Journal: Cancers (Basel) Date: 2022-06-16 Impact factor: 6.575