Literature DB >> 2939365

The stereoselectivity of serotonin uptake in brain tissue and blood platelets: the topography of the serotonin uptake area.

D F Smith.   

Abstract

This review concerns effects of stereoisomers on 5-HT uptake in brain tissue and/or blood platelets. All studies in which at least a pair of stereoisomers were used are considered. Differences between effects of stereoisomers of antidepressants as well as other drugs on 5-HT uptake are discussed. The findings indicate that 5-HT uptake is a stereoselective process. A topographical model of the 5-HT uptake area is proposed, based mainly on comparisons between spatial features of stereoisomers that inhibit 5-HT uptake.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 2939365     DOI： 10.1016/0149-7634(86)90031-x

Source DB:  PubMed          Journal:  Neurosci Biobehav Rev        ISSN： 0149-7634            Impact factor:   8.989


  4 in total

1.  Interaction of the central analgesic, tramadol, with the uptake and release of 5-hydroxytryptamine in the rat brain in vitro.

Authors:  B Driessen; W Reimann
Journal:  Br J Pharmacol       Date:  1992-01       Impact factor: 8.739

Review 2.  Binding of some antidepressants to the 5-hydroxytryptamine transporter in brain and platelets.

Authors:  J O Marcusson; S B Ross
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

3.  Effects of 3,N,N'-trimethyl-2-phenyl-1,4-piperazine diastereomers on monoamine uptake and monoamine oxidase in rat brain.

Authors:  D F Smith; P N Jensen; M Gelbcke; D Tytgat
Journal:  J Neural Transm Gen Sect       Date:  1992

4.  Serotonin receptor subtype mediation of the interoceptive discriminative stimuli induced by 5-methoxy-N,N-dimethyltryptamine.

Authors:  D G Spencer; T Glaser; J Traber
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.