Literature DB >> 2939344

Metabolism of ethanol in vitro produces a compound which induces sister-chromatid exchanges in human peripheral lymphocytes in vitro: acetaldehyde not ethanol is mutagenic.

G Obe, R Jonas, S Schmidt.   

Abstract

Ethanol (EtOH) in the presence of the EtOH-metabolizing enzyme, alcohol dehydrogenase (ADH) leads to the induction of sister-chromatid exchanges (SCEs) in human peripheral lymphocytes in vitro. Acetaldehyde (AA) induces SCEs, whose frequencies are lowered in the presence of the AA-metabolizing enzyme, aldehyde dehydrogenase (ALDH). EtOH in the presence of ADH produces more SCEs than EtOH in the presence of ADH and ALDH. These data are interpreted to show that not ethanol itself, but its first metabolite acetaldehyde is mutagenic.

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Year:  1986        PMID： 2939344     DOI： 10.1016/0165-7992(86)90075-8

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  14 in total

1.  Association between ADH1B and ADH1C polymorphisms and the risk of head and neck squamous cell carcinoma.

Authors:  Yong Bae Ji; Seung Hwan Lee; Kyung Rae Kim; Chul Won Park; Chang Myeon Song; Byung Lae Park; Hyoung Doo Shin; Kyung Tae
Journal:  Tumour Biol       Date:  2015-01-21

2.  Effects of genetic polymorphisms in alcohol-metabolizing enzymes on alcohol hypersensitivity and alcohol-related health problems in orientals.

Authors:  T Takeshita; K Morimoto
Journal:  Environ Health Prev Med       Date:  1996-04       Impact factor: 3.674

3.  Alcohol intake and folate antagonism via CYP2E1 and ALDH1: effects on oral carcinogenesis.

Authors:  Phillip H Hwang; Lisa Lian; Athanasios I Zavras
Journal:  Med Hypotheses       Date:  2011-11-17       Impact factor: 1.538

4.  Increased cancer risk in heavy drinkers with the alcohol dehydrogenase 1C*1 allele, possibly due to salivary acetaldehyde.

Authors:  J P Visapää; K Götte; M Benesova; J Li; N Homann; C Conradt; H Inoue; M Tisch; K Hörrmann; S Väkeväinen; M Salaspuro; H K Seitz
Journal:  Gut       Date:  2004-06       Impact factor: 23.059

5.  Acetaldehyde as an underestimated risk factor for cancer development: role of genetics in ethanol metabolism.

Authors:  Helmut K Seitz; Felix Stickel
Journal:  Genes Nutr       Date:  2009-10-22       Impact factor: 5.523

Review 6.  [Alcohol related diseases of the head and neck].

Authors:  F Riedel; K Hörmann
Journal:  HNO       Date:  2004-07       Impact factor: 1.284

Review 7.  Modification of stem cell states by alcohol and acetaldehyde.

Authors:  Ryan N Serio; Lorraine J Gudas
Journal:  Chem Biol Interact       Date:  2019-12-14       Impact factor: 5.192

8.  Low Km aldehyde dehydrogenase (ALDH2) polymorphism, alcohol-drinking behavior, and chromosome alterations in peripheral lymphocytes.

Authors:  K Morimoto; T Takeshita
Journal:  Environ Health Perspect       Date:  1996-05       Impact factor: 9.031

9.  Drinking alcohol is associated with variation in the human oral microbiome in a large study of American adults.

Authors:  Xiaozhou Fan; Brandilyn A Peters; Eric J Jacobs; Susan M Gapstur; Mark P Purdue; Neal D Freedman; Alexander V Alekseyenko; Jing Wu; Liying Yang; Zhiheng Pei; Richard B Hayes; Jiyoung Ahn
Journal:  Microbiome       Date:  2018-04-24       Impact factor: 14.650

Review 10.  Alcohol metabolism and cancer risk.

Authors:  Helmut K Seitz; Peter Becker
Journal:  Alcohol Res Health       Date:  2007
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