Fausto Petrelli1, Raffaele Ardito2, Antonio Ghidini3, Alberto Zaniboni4, Michele Ghidini5, Sandro Barni1, Gianluca Tomasello5. 1. Oncology Unit, Oncology Department, ASST Bergamo Ovest, Treviglio, Italy. 2. IRCCS Centro di Riferimento Oncologico della Basilicata (CROB), Rionero in Vulture, Italy. 3. Medical Oncology, Casa di Cura Igea, Milan, Italy. 4. Oncology Unit, Fondazione Poliambulanza, Brescia, Italy. 5. Oncology Unit, Oncology Department, ASST Ospedale di Cremona, Cremona, Italy.
Abstract
BACKGROUND: Over the last few years only one large randomized phase III study has tried to prospectively assess the safety of cetuximab and panitumumab in a head-to-head comparison. Despite the similar overall toxicity profile, cetuximab and panitumumab retain peculiar safety characteristics that deserve to be deeply investigated. METHODS: We conducted a systematic review for randomized trials in PubMed, the Cochrane Central Register of Controlled Trials, SCOPUS, Web of Science, and EMBASE using the terms ("cetuximab" or "panitumumab") AND ("colorectal cancer" OR "colorectal carcinoma"). Data of adverse events were aggregated to obtain pooled incidence rates of prespecified adverse events. Incidence of skin toxicities was the primary outcome. A χ2 test was used for comparisons of proportions and an odds ratio (OR) was calculated for comparison. RESULTS: A total of 38 studies were included for analysis. Cetuximab was associated with fewer G3-4 skin toxicities (OR = 0.62, 95% CI 0.53-0.62; p < 0.001), slightly more frequent G3-4 acne-like rash (OR = 1.24, 95% CI 1.04-1.48; p = 0.04), and paronychia (OR 1.36, 95% CI 1.1-1.7), but fewer cases of skin fissures (OR = 0.64, 95% CI 0.44-0.93; p = 0.02) and pruritus (OR = 0.45, 95% CI 0.35-0.58; p < 0.001) than PANI. CONCLUSIONS: In conclusion, this meta-analysis shows that cetuximab- and panitumumab-based chemotherapy have different toxicity profiles in terms of the rate of severe adverse events.
BACKGROUND: Over the last few years only one large randomized phase III study has tried to prospectively assess the safety of cetuximab and panitumumab in a head-to-head comparison. Despite the similar overall toxicity profile, cetuximab and panitumumab retain peculiar safety characteristics that deserve to be deeply investigated. METHODS: We conducted a systematic review for randomized trials in PubMed, the Cochrane Central Register of Controlled Trials, SCOPUS, Web of Science, and EMBASE using the terms ("cetuximab" or "panitumumab") AND ("colorectal cancer" OR "colorectal carcinoma"). Data of adverse events were aggregated to obtain pooled incidence rates of prespecified adverse events. Incidence of skin toxicities was the primary outcome. A χ2 test was used for comparisons of proportions and an odds ratio (OR) was calculated for comparison. RESULTS: A total of 38 studies were included for analysis. Cetuximab was associated with fewer G3-4 skin toxicities (OR = 0.62, 95% CI 0.53-0.62; p < 0.001), slightly more frequent G3-4 acne-like rash (OR = 1.24, 95% CI 1.04-1.48; p = 0.04), and paronychia (OR 1.36, 95% CI 1.1-1.7), but fewer cases of skin fissures (OR = 0.64, 95% CI 0.44-0.93; p = 0.02) and pruritus (OR = 0.45, 95% CI 0.35-0.58; p < 0.001) than PANI. CONCLUSIONS: In conclusion, this meta-analysis shows that cetuximab- and panitumumab-based chemotherapy have different toxicity profiles in terms of the rate of severe adverse events.
Authors: Emanuela Dell'Aquila; Tea Zeppola; Marco Stellato; Francesco Pantano; Mario Scartozzi; Cristina Madaudo; Filippo Pietrantonio; Chiara Cremolini; Giuseppe Aprile; Bruno Vincenzi; Roberto Moretto; Marco Puzzoni; Silvio Ken Garattini; Riccardo Lobefaro; Giuseppe Tonini; Daniele Santini Journal: Clin Med Insights Oncol Date: 2020-08-04