OBJECTIVE: Human papillomavirus (HPV) vaccination is currently not included in the national vaccination program in Iran. Regional data on the distribution of HPV types in women are important as they can predict the impact of currently available vaccines and help health policy makers to consider all the possibilities with regard to HPV vaccination. METHODS: A total of 1,218 Iranian women with normal cervical cytology were included in this study. The presence of the HPV genome was investigated in all specimens by PCR assay, and all HPV-positive samples were genotyped. RESULTS: Totally, HPV was detected in 88 samples (7.2%). According to different geographical regions, the HPV prevalence varied: the highest HPV prevalence was observed in the North (11.7%) and the lowest in the Center (4.5%) of Iran, and this difference reached a statistically significant level (p < 0.05). In this study, the most frequent HPV types were HPV 16, 18, 66, and 11, representing 63.8% of all HPV infections. CONCLUSION: Based on this study, it is estimated that HPV vaccines could have a great impact on the prevention of cervical cancer in Iran. This study highlights the necessity of introducing educational programs in high schools, robust screening programs, and vaccination in Iran.
OBJECTIVE:Human papillomavirus (HPV) vaccination is currently not included in the national vaccination program in Iran. Regional data on the distribution of HPV types in women are important as they can predict the impact of currently available vaccines and help health policy makers to consider all the possibilities with regard to HPV vaccination. METHODS: A total of 1,218 Iranian women with normal cervical cytology were included in this study. The presence of the HPV genome was investigated in all specimens by PCR assay, and all HPV-positive samples were genotyped. RESULTS: Totally, HPV was detected in 88 samples (7.2%). According to different geographical regions, the HPV prevalence varied: the highest HPV prevalence was observed in the North (11.7%) and the lowest in the Center (4.5%) of Iran, and this difference reached a statistically significant level (p < 0.05). In this study, the most frequent HPV types were HPV 16, 18, 66, and 11, representing 63.8% of all HPV infections. CONCLUSION: Based on this study, it is estimated that HPV vaccines could have a great impact on the prevention of cervical cancer in Iran. This study highlights the necessity of introducing educational programs in high schools, robust screening programs, and vaccination in Iran.
Authors: Marcelo de Andrade Vieira; Raphael Leonardo Cunha de Araújo; Carlos Eduardo Mattos da Cunha Andrade; Ronaldo Luis Schmidt; Agnaldo Lopes Filho; Ricardo Dos Reis Journal: PLoS One Date: 2021-01-20 Impact factor: 3.240
Authors: Mona Sadat Larijani; Mir Davood Omrani; Rahim Soleimani; Anahita Bavand; Amir Houshang Nejadeh; Vahid Ezzatizadeh; Mahboubeh Jamshidi; Amitis Ramezani Journal: Biomed Res Int Date: 2022-03-18 Impact factor: 3.411
Authors: Lucy Wanja Karani; Stanslaus Musyoki; Robert Orina; Anthony Kebira Nyamache; Christopher Khayeka-Wandabwa; Benuel Nyagaka Journal: Pan Afr Med J Date: 2020-03-10