Laura Duque-Serrano1,2, Liliana Patarroyo-Rodriguez1,2, Dorothy Gotlib3, Juan C Molano-Eslava4,5,6. 1. FundaMental Research Group, Psychiatry and Mental Health Department, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá, Colombia. 2. Universidad de los Andes, School of Medicine, Bogotá, Colombia. 3. Department of Psychiatry, Michigan Medicine, Ann Arbor, MI, USA. 4. FundaMental Research Group, Psychiatry and Mental Health Department, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá, Colombia. molanojuan@hotmail.com. 5. Universidad de los Andes, School of Medicine, Bogotá, Colombia. molanojuan@hotmail.com. 6. Head of Mental Health and Psychiatry Department, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá, Colombia. molanojuan@hotmail.com.
Abstract
PURPOSE OF REVIEW: The aim of this paper is to review psychiatric manifestations, comorbidities, and psychopharmacological management in individuals with acute porphyria (AP). RECENT FINDINGS: Recent literature begins to clarify associations between AP, schizophrenia, bipolar disorder, and other psychopathology. Broad psychiatric symptoms have been associated to acute porphyria (AP) and correspond to a spectrum of heterogeneous manifestations such as anxiety, affective alterations, behavioral changes, personality, and psychotic symptoms. These symptoms may be difficult to identify as being related to porphyria since symptoms may arise at any time during the disease process. In addition, these patients may present psychiatric conditions secondary to the disease, such as adjustment disorder and substance use disorders. Timely diagnosis and appropriate treatment of psychiatric manifestations positively impact the course of the disease.
PURPOSE OF REVIEW: The aim of this paper is to review psychiatric manifestations, comorbidities, and psychopharmacological management in individuals with acute porphyria (AP). RECENT FINDINGS: Recent literature begins to clarify associations between AP, schizophrenia, bipolar disorder, and other psychopathology. Broad psychiatric symptoms have been associated to acute porphyria (AP) and correspond to a spectrum of heterogeneous manifestations such as anxiety, affective alterations, behavioral changes, personality, and psychotic symptoms. These symptoms may be difficult to identify as being related to porphyria since symptoms may arise at any time during the disease process. In addition, these patients may present psychiatric conditions secondary to the disease, such as adjustment disorder and substance use disorders. Timely diagnosis and appropriate treatment of psychiatric manifestations positively impact the course of the disease.
Authors: Teryl K Nuckols; Laura Anderson; Ioana Popescu; Allison L Diamant; Brian Doyle; Paul Di Capua; Roger Chou Journal: Ann Intern Med Date: 2014-01-07 Impact factor: 25.391
Authors: Avishek Adhikari; Carlos A A Penatti; Rodrigo R Resende; Henning Ulrich; Luiz R G Britto; Etelvino J H Bechara Journal: Brain Res Date: 2006-05-15 Impact factor: 3.252