Seok Hoon Lee1, Doo Yeoun Cho2, Nam Seok Joo1, Kwang Min Kim1, Kyu Nam Kim1. 1. Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon, South Korea. 2. Department of Family Medicine, CHA University, CHA Bundang Medical Center, Seongnam, South Korea.
Abstract
BACKGROUND/AIMS: Although associations between serum alanine aminotransferase and metabolic syndrome are well-recognized in Western countries, only a limited number of prospective studies have been performed in Asian populations. The aim of the study was to cross-sectionally and longitudinally examine whether serum alanine aminotransferase levels are associated with metabolic syndrome and its associated components in a Korean population. MATERIALS AND METHODS: A total of 31,832 subjects who received health screenings were included in cross-sectional analyses; a subgroup of 4.070 subjects without metabolic syndrome at baseline was included in the longitudinal analyses. The metabolic syndrome definition was based on the National Cholesterol Education Program Third Adult Treatment Panel criteria with modification on waist circumference cut-off to be more appropriate for an Asian population. RESULTS: In the cross-sectional analyses, serum alanine aminotransferase is positively associated with metabolic syndrome and its components. In the longitudinal analyses, the prevalence of metabolic syndrome increased across serum alanine aminotransferase quartiles in a dose-dependent manner after extensive adjustments (hazard ratios were 1.000, 1.609, 2.601, and 3.015 for quartiles, 1 through quartile 4; P for trend<0.001). CONCLUSION: Our study confirmed a positive association between components of metabolic syndrome and elevated serum alanine aminotransferase in a Korean population.
BACKGROUND/AIMS: Although associations between serum alanine aminotransferase and metabolic syndrome are well-recognized in Western countries, only a limited number of prospective studies have been performed in Asian populations. The aim of the study was to cross-sectionally and longitudinally examine whether serum alanine aminotransferase levels are associated with metabolic syndrome and its associated components in a Korean population. MATERIALS AND METHODS: A total of 31,832 subjects who received health screenings were included in cross-sectional analyses; a subgroup of 4.070 subjects without metabolic syndrome at baseline was included in the longitudinal analyses. The metabolic syndrome definition was based on the National Cholesterol Education Program Third Adult Treatment Panel criteria with modification on waist circumference cut-off to be more appropriate for an Asian population. RESULTS: In the cross-sectional analyses, serum alanine aminotransferase is positively associated with metabolic syndrome and its components. In the longitudinal analyses, the prevalence of metabolic syndrome increased across serum alanine aminotransferase quartiles in a dose-dependent manner after extensive adjustments (hazard ratios were 1.000, 1.609, 2.601, and 3.015 for quartiles, 1 through quartile 4; P for trend<0.001). CONCLUSION: Our study confirmed a positive association between components of metabolic syndrome and elevated serum alanine aminotransferase in a Korean population.
Authors: Víctor Micó; Rodrigo San-Cristobal; Roberto Martín; Miguel Ángel Martínez-González; Jordi Salas-Salvadó; Dolores Corella; Montserrat Fitó; Ángel M Alonso-Gómez; Julia Wärnberg; Jesús Vioque; Dora Romaguera; José López-Miranda; Ramon Estruch; Francisco J Tinahones; José Lapetra; J Luís Serra-Majem; Aurora Bueno-Cavanillas; Josep A Tur; Vicente Martín Sánchez; Xavier Pintó; Miguel Delgado-Rodríguez; Pilar Matía-Martín; Josep Vidal; Clotilde Vázquez; Ana García-Arellano; Salvador Pertusa-Martinez; Alice Chaplin; Antonio Garcia-Rios; Carlos Muñoz Bravo; Helmut Schröder; Nancy Babio; Jose V Sorli; Jose I Gonzalez; Diego Martinez-Urbistondo; Estefania Toledo; Vanessa Bullón; Miguel Ruiz-Canela; María Puy- Portillo; Manuel Macías-González; Nuria Perez-Diaz-Del-Campo; Jesús García-Gavilán; Lidia Daimiel; J Alfredo Martínez Journal: Front Endocrinol (Lausanne) Date: 2022-09-06 Impact factor: 6.055