| Literature DB >> 29391169 |
Ya-Lin Hu1, Yi Li2, Lu Qiu2, Jun-He Li1, Li Heng2, Shan-Shan Wei1, Hong-Liang Gao1, Xiao-Bing Wang1, Jun Luo3, Ling-Yi Kong4.
Abstract
Nine new euphane- and apotirucallane-type triterpenoids (Toosendines A-I; 1-9), along with three known tirucallane-type compounds were isolated from the barks of Melia toosendan. Their structures were elucidated based on detailed spectroscopic analyses (HRESIMS, 1D/2D-NMR) and circular dichroism spectra. Results of bioactivities screening exhibited that compounds 1, 4 and 5 showed remarkable NO inhibitory activities in LPS-activated RAW 264.7 macrophages, meanwhile, compounds 1 and 4 showed moderate cytotoxicities against U2OS human cancer cell line.Entities:
Keywords: Anti-inflammatory; Circular Dichroism; Cytotoxicity; Ethanol (PubChem CID: 702); Melia toosendan; Methanol (PubChem CID: 887); Methyl cyanide (PubChem CID: 6432); Methylene chloride (PubChem CID: 6344); Triterpenoids
Mesh：
Substances：
Year: 2018 PMID： 29391169 DOI： 10.1016/j.fitote.2018.01.011
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882