Correction: An ImmunoSignature test distinguishes Trypanosoma cruzi, hepatitis B, hepatitis C and West Nile virus seropositivity among asymptomatic blood donors.

[This corrects the article DOI: 10.1371/journal.pntd.0005882.].

There are errors in Tables 3–5 which arose during typesetting. The publisher apologizes for these errors.

Table 3

Top ranking alignments of informative library peptides to the T. cruzi proteome.

	T. cruzi protein	TotalScore	Target 20mer	# peptide hits	TrTrypDB Gene ID
1	Mucin: TcMucII*	3473	TRAPSRLREVDGSLGSSAWV	63	TcCLB.509753.300
2	Uncharacterized protein	3329	RRLSYRLRKREDGESYESYL	59	TcCLB.510575.140
3	Uncharacterized protein	3181	VPVLRVVDAEADERERNGAG	56	TCSYLVIO_001012
4	Calmodulin*	3096	TEVDVREALRVLDADGDGFL	57	TcCLB.510121.50
5	Uncharacterized protein	3091	SYRQQRYVDALRFALEEDHE	56	TcCLB.508269.50
6	Mucin: TcMucII*	3032	RAPSRLREFDGSLSSSAWVC	56	TcCLB.506741.110
7	Uncharacterized protein	3007	KLRQLDFVEDVLRKHPDKVE	52	TcCLB.507011.170
8	Dispersed gene family protein 1 (DGF-1)*	2983	HRGGLEALLRDGEDGDEDAQ	58	TcCLB.509735.84
9	Uncharacterized protein	2973	LPAQDSVVVRRLVDGQAPLR	51	TcCLB.506267.48
10	Vacuolar protein sorting-associated protein (Vps26)	2966	ERSPGLLGRLLRKVDGCDVR	52	TCSYLVIO_008174

* The families in which these proteins are members have been previously identified as antigenic

Table 5

Confusion matrix and performance estimates of the multiclass prediction model.

IST Classification	Blood Bank Confirmed Diagnosis				Performance Summary
	T. cruzi +	HBV+	HCV+	WNV+	Sensa	Specb	AUC
T. cruzi+	77	3	1	2	93%	96%	0.98
HBV+	3	79	12	2	82%	96%	0.96
HCV+	0	3	55	2	92%	94%	0.95
WNV+	8	3	3	82	85%	97%	0.97
Totals	88	88	71	88	Overall accuracy = 87%

aSens, sensitivity

bSpec, specificity

Table 4

Binary classification of each of four disease classes versus a combined class of the remaining three.

Classes	AUC	Sensitivity@90% speca	Specificity@90% sensb	Accuracy@speca=sensb	Model size(k)
T. cruzi vs.Other	0.97(0.96-0.98)	92%(90%-94%)	94%(90%-96%)	92%(90%-92%)	50
HBV vs.Other	0.94(0.93-0.95)	85%(78%-90%)	85%(78%-90%)	87%(85%-90%)	16000
HCV vs.Other	0.96(0.94-0.97)	90%(86%-94%)	91%(82%-96%)	90%(88%-93%)	100
WNV vs.Other	0.96(0.95-0.97)	87%(78%-94%)	88%(84%-92%)	89%(86%-91%)	1000

aspec, specificity

bsens, sensitivity