Literature DB >> 2938975

Influence of carriers on the development and localization of anti-2,4,6-trinitrophenyl (TNP) antibody-forming cells in the murine spleen. II. Suppressed antibody response to TNP-Ficoll after elimination of marginal zone cells.

E Claassen, N Kors, N Van Rooijen.   

Abstract

The macrophages in the marginal zones in mice spleens were eliminated by i.v. injection of dichloromethylene diphosphonate encapsulated in liposomes. After immunization with a thymus-dependent (trinitrophenylated keyhole limpet hemocyanin; TNP-KLH) or thymus-independent type 1 (TNP-lipopolysaccharide) antigen, no differences in antibody responses in treated and untreated mice were observed. However, immunization with a thymus-independent type 2 (TI-2) antigen (TNP-Ficoll) resulted in a strong decrease of the antibody response in macrophage-depleted animals. Anti-TNP serum levels dropped 10-fold and the number of antibody-forming cells in the spleen 30-60-fold. These results confirm the special role of the marginal zone macrophages in the processing of TI-2 antigens, as earlier suggested in splenectomy studies.

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Year:  1986        PMID： 2938975     DOI： 10.1002/eji.1830160505

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  16 in total

Review 1.  Recent advances in the detection and characterization of specific antibody-forming cells in tissue sections.

Authors:  N Van Rooijen; E Claassen
Journal:  Histochem J       Date:  1986-09

2.  The role of macrophages in the immunoadjuvant action of liposomes: effects of elimination of splenic macrophages on the immune response against intravenously injected liposome-associated albumin antigen.

Authors:  D Su; N Van Rooijen
Journal:  Immunology       Date:  1989-03       Impact factor: 7.397

3.  The role of macrophages in LPS-induced lethality and tissue injury.

Authors:  P H Groeneveld; E Claassen; C F Kuper; N Van Rooijen
Journal:  Immunology       Date:  1988-03       Impact factor: 7.397

4.  Fetal and neonatal development of human spleen: an immunohistological study.

Authors:  W Timens; T Rozeboom; S Poppema
Journal:  Immunology       Date:  1987-04       Impact factor: 7.397

5.  Increased adjuvant efficacy in stimulation of antibody responses after macrophage elimination in vivo.

Authors:  P P Leenaars; H F Savelkoul; C F Hendriksen; N Van Rooijen; E Claassen
Journal:  Immunology       Date:  1997-03       Impact factor: 7.397

6.  Marginal zone B cells regulate antigen capture by marginal zone macrophages.

Authors:  Yuying You; Riley C Myers; Larry Freeberg; Jeremy Foote; John F Kearney; Louis B Justement; Robert H Carter
Journal:  J Immunol       Date:  2011-01-21       Impact factor: 5.422

7.  Splenic autotransplantation and the immune system. Adequate testing required for evaluation of effect.

Authors:  W Timens; R Leemans
Journal:  Ann Surg       Date:  1992-03       Impact factor: 12.969

8.  Staphylococcal toxin induced preferential and prolonged in vivo deletion of innate-like B lymphocytes.

Authors:  Carl S Goodyear; Gregg J Silverman
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-23       Impact factor: 11.205

9.  Fixation of cryo-sections under HIV-1 inactivating conditions: integrity of antigen binding sites and cell surface antigens.

Authors:  J D Laman; N Kors; J L Heeney; W J Boersma; E Claassen
Journal:  Histochemistry       Date:  1991

10.  Immunomodulation with liposomes: the immune response elicited by liposomes with entrapped dichloromethylene-diphosphonate and surface-associated antigen or hapten.

Authors:  E Claassen; N Kors; N van Rooijen
Journal:  Immunology       Date:  1987-04       Impact factor: 7.397
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