| Literature DB >> 29389517 |
Abstract
Wnt signaling in stem cells plays critical roles in development, normal adult physiology, and disease. In this chapter, we focus on the role of the Wnt signaling pathway in somatic stem cell biology and its critical role in normal tissue homeostasis and cancer. Wnt signaling can both maintain potency and initiate differentiation in somatic stem cells, depending on the cellular and environmental context. Based principally on studies from our lab, we will explain the dichotomous behavior of this signaling pathway in determining stem cell fate decisions, placing special emphasis on the interaction of β-catenin with either of the two highly homologous Kat3 coactivator proteins, CBP and p300. We will also discuss our results, both preclinical and clinical, demonstrating that small molecule modulators of the β-catenin/Kat3 coactivator interaction can be safely utilized to shift the balance between maintenance of potency and initiation of differentiation.Entities:
Keywords: CBP; CREB-binding protein; CSC; E1A binding protein p300; ES; LSC/LIC; SSC; Wnt pathway; cancer stem cell; embryonic stem cell; iPS; induced pluripotent stem cell; leukemic stem cell/initiating cell; p300; somatic stem cell
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Year: 2017 PMID： 29389517 DOI： 10.1016/bs.pmbts.2017.11.007
Source DB: PubMed Journal: Prog Mol Biol Transl Sci ISSN： 1877-1173 Impact factor: 3.622