| Literature DB >> 29389515 |
Francesco Girardi1, Fabien Le Grand2.
Abstract
Wnt is a family of signaling molecules involved in embryogenesis, adult tissue repair, and cancer. They activate canonical and noncanonical Wnt signaling cascades in target cells. Several studies, within the last decades, showed that several Wnt ligands are involved in myogenesis and both canonical and noncanonical Wnt pathways regulate muscle formation and the maintenance of adult tissue homeostasis. In this review, we provide a comprehensive overview of the roles of Wnt signaling during muscle development and an updated description of Wnt functions during muscle repair. Lastly, we discuss the crosstalk between Wnt and TGFβ signaling pathways in skeletal muscle.Entities:
Keywords: Wnt; Wnt/TGFβ crosstalk; muscle regeneration; myofibers; myogenesis; satellite cells; skeletal muscle
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Year: 2018 PMID: 29389515 DOI: 10.1016/bs.pmbts.2017.11.026
Source DB: PubMed Journal: Prog Mol Biol Transl Sci ISSN: 1877-1173 Impact factor: 3.622