BACKGROUND: Perioperative bleeding complications of ticagrelor, a newer oral antiplatelet, has not been studied in dentistry. Studies about bleeding status after oral surgical procedures in patients receiving continued antiplatelet therapy are also limited. We investigated the effects of continuing aspirin, clopidogrel, ticagrelor, or dual antiplatelet therapy on the frequency of bleeding events in patients undergoing tooth extractions or minor oral surgery. METHODS: In this retrospective study, patient demographic characteristics, medical history, type of antiplatelet therapy, dental procedures, and perioperative bleeding associated with tooth extraction or other minor oral surgical procedures were obtained from the dental records of 222 patients. Bleeding was classified as normal, mild, moderate, or severe. RESULTS: One hundred sixty-eight patients (75.7%) had 1 or more teeth extracted, and 54 patients (24.3%) underwent other minor oral surgical procedures. The most common single antiplatelet regimen was aspirin (n = 123; 55.4%), followed by clopidogrel (n = 22; 9.9%) and ticagrelor (n = 17; 7.7%). Sixty patients (27%) received dual antiplatelet therapy. The overall frequency of postoperative bleeding was 4.9% (11 of 222). The frequencies of postoperative bleeding in the aspirin, clopidogrel, ticagrelor, and dual antiplatelet therapy groups were 3.2%, 4.5%, 5.9%, and 8.3%, respectively (P ≥ .5). None of the patients experienced prolonged bleeding. CONCLUSIONS: Patients taking aspirin, clopidogrel, ticagrelor, and dual antiplatelet therapy experienced acceptable rates of controllable postoperative bleeding after tooth extraction or minor oral surgical procedures. PRACTICAL IMPLICATIONS: In accordance with recommendations from published studies and guidelines, antiplatelet medications, including dual antiplatelet therapy, should not be interrupted for tooth extractions or minor oral surgery.
BACKGROUND: Perioperative bleeding complications of ticagrelor, a newer oral antiplatelet, has not been studied in dentistry. Studies about bleeding status after oral surgical procedures in patients receiving continued antiplatelet therapy are also limited. We investigated the effects of continuing aspirin, clopidogrel, ticagrelor, or dual antiplatelet therapy on the frequency of bleeding events in patients undergoing tooth extractions or minor oral surgery. METHODS: In this retrospective study, patient demographic characteristics, medical history, type of antiplatelet therapy, dental procedures, and perioperative bleeding associated with tooth extraction or other minor oral surgical procedures were obtained from the dental records of 222 patients. Bleeding was classified as normal, mild, moderate, or severe. RESULTS: One hundred sixty-eight patients (75.7%) had 1 or more teeth extracted, and 54 patients (24.3%) underwent other minor oral surgical procedures. The most common single antiplatelet regimen was aspirin (n = 123; 55.4%), followed by clopidogrel (n = 22; 9.9%) and ticagrelor (n = 17; 7.7%). Sixty patients (27%) received dual antiplatelet therapy. The overall frequency of postoperative bleeding was 4.9% (11 of 222). The frequencies of postoperative bleeding in the aspirin, clopidogrel, ticagrelor, and dual antiplatelet therapy groups were 3.2%, 4.5%, 5.9%, and 8.3%, respectively (P ≥ .5). None of the patients experienced prolonged bleeding. CONCLUSIONS:Patients taking aspirin, clopidogrel, ticagrelor, and dual antiplatelet therapy experienced acceptable rates of controllable postoperative bleeding after tooth extraction or minor oral surgical procedures. PRACTICAL IMPLICATIONS: In accordance with recommendations from published studies and guidelines, antiplatelet medications, including dual antiplatelet therapy, should not be interrupted for tooth extractions or minor oral surgery.
Authors: Thayanne Barbosa Brasil Calcia; Harry Juan Rivera Oballe; Alice Maria de Oliveira Silva; Stephanie Anagnostopoulos Friedrich; Francisco Wilker Mustafa Gomes Muniz Journal: Clin Oral Investig Date: 2021-03-23 Impact factor: 3.573
Authors: Gabriele Cervino; Luca Fiorillo; Ines Paola Monte; Rosa De Stefano; Luigi Laino; Salvatore Crimi; Alberto Bianchi; Alan Scott Herford; Antonio Biondi; Marco Cicciù Journal: Materials (Basel) Date: 2019-05-09 Impact factor: 3.623
Authors: Mariano Sanz; Alvaro Marco Del Castillo; Søren Jepsen; Jose R Gonzalez-Juanatey; Francesco D'Aiuto; Philippe Bouchard; Iain Chapple; Thomas Dietrich; Israel Gotsman; Filippo Graziani; David Herrera; Bruno Loos; Phoebus Madianos; Jean-Baptiste Michel; Pablo Perel; Burkert Pieske; Lior Shapira; Michael Shechter; Maurizio Tonetti; Charalambos Vlachopoulos; Gernot Wimmer Journal: J Clin Periodontol Date: 2020-02-03 Impact factor: 8.728
Authors: Esther Martínez-Moreno; Federico Martínez-López; Francisco Javier Rodríguez-Lozano; Ricardo Elías Oñate-Sánchez Journal: Int J Environ Res Public Health Date: 2021-02-08 Impact factor: 3.390
Authors: M Sanz; A Marco Del Castillo; S Jepsen; J R Gonzalez-Juanatey; F D'Aiuto; P Bouchard; I Chapple; T Dietrich; I Gotsman; F Graziani; D Herrera; B Loos; P Madianos; J B Michel; P Perel; B Pieske; L Shapira; M Shechter; M Tonetti; C Vlachopoulos; G Wimmer Journal: Glob Heart Date: 2020-02-03