Sun Young Choi1, Ji Yeon Hong2, Eun Jung Ko3, Beom Joon Kim2, Sung-Woon Hong4, Mi Hyoung Lim4, Sung Hum Yeon5, Rak Ho Son5. 1. a Department of Dermatology, Seoul Paik Hospital , Inje University College of Medicine , Seoul , Korea. 2. b Department of Dermatology , Chung-Ang University College of Medicine , Seoul , Korea. 3. c Department of Dermatology, Myongji Hospital , Seonam University College of Medicine , Goyang , Korea. 4. d Department of Clinical Research & Medical information , Huons Co., Ltd ., Gyeonggi-do , Korea. 5. e Botanical Drug Research Team , Huons Co., Ltd ., Gyeonggi-do , Korea.
Abstract
BACKGROUND: Oxidative stress and photodamage resulting from ultraviolet radiation exposure play key roles in skin aging. Fermented Cyclopia intermedia, which is used to brew honeybush tea, exerts antioxidant and anti-wrinkle effects by inhibiting reactive oxygen species production and downregulating matrix metalloproteinase activity. OBJECTIVES: This randomized, double-blinded, placebo-controlled study aimed to evaluate the efficacy and safety of fermented honeybush (Cyclopia intermedia) extract (HU-018) for skin rejuvenation. METHODS:120 Korean subjects with crow's feet wrinkles were randomized to receive either low-dose extract (400 mg/day), high-dose extract (800 mg/day), or placebo (negative control, only dextran) for 12 weeks. Wrinkles were evaluated using JANUS® and PRIMO pico®. Skin elasticity, hydration and transepidermal water loss were measured. RESULTS:Global skin wrinkle grade was significantly improved in both low-dose and high-dose groups compared to placebo group, as well as for skin hydration and elasticity. Both the low- and high-dose groups showed significantly decreased TEWL compared to the placebo group. There were no adverse effects during the entire study period. CONCLUSION: Our data indicate that HU-018 is effective for improving skin wrinkles, elasticity, and hydration. Therefore, daily supplementation with fermented honeybush could be helpful for protecting against skin aging.
RCT Entities:
BACKGROUND: Oxidative stress and photodamage resulting from ultraviolet radiation exposure play key roles in skin aging. Fermented Cyclopia intermedia, which is used to brew honeybush tea, exerts antioxidant and anti-wrinkle effects by inhibiting reactive oxygen species production and downregulating matrix metalloproteinase activity. OBJECTIVES: This randomized, double-blinded, placebo-controlled study aimed to evaluate the efficacy and safety of fermented honeybush (Cyclopia intermedia) extract (HU-018) for skin rejuvenation. METHODS: 120 Korean subjects with crow's feet wrinkles were randomized to receive either low-dose extract (400 mg/day), high-dose extract (800 mg/day), or placebo (negative control, only dextran) for 12 weeks. Wrinkles were evaluated using JANUS® and PRIMO pico®. Skin elasticity, hydration and transepidermal water loss were measured. RESULTS: Global skin wrinkle grade was significantly improved in both low-dose and high-dose groups compared to placebo group, as well as for skin hydration and elasticity. Both the low- and high-dose groups showed significantly decreased TEWL compared to the placebo group. There were no adverse effects during the entire study period. CONCLUSION: Our data indicate that HU-018 is effective for improving skin wrinkles, elasticity, and hydration. Therefore, daily supplementation with fermented honeybush could be helpful for protecting against skin aging.
Authors: H J Chen; P Y Lee; C Y Chen; S L Huang; B W Huang; F J Dai; C F Chau; C S Chen; Y S Lin Journal: Sci Rep Date: 2022-06-17 Impact factor: 4.996
Authors: Su Jin Lee; Ji Eun Kim; Yun Ju Choi; Jeong Eun Gong; So Hae Park; Bounleuane Douangdeuane; Onevilay Souliya; Ju Min Park; Hee Seob Lee; Bae-Hwan Kim; Dae Youn Hwang Journal: Antioxidants (Basel) Date: 2021-05-17