| Literature DB >> 29388780 |
Fei-Hu Cui1,2, Jing Chen2, Zu-Yu Mo2, Shi-Xia Su2, Yan-Yan Chen1, Xian-Li Ma1, Hai-Tao Tang2, Heng-Shan Wang2, Ying-Ming Pan2, Yan-Li Xu1,2.
Abstract
A simple and efficient Cu-catalyzed decarboxylative/click reaction for the preparation of 1,4-disubstituted 5-arylselanyl-1,2,3-triazoles from propiolic acids, diselenides, and azides has been developed. The mechanistic study revealed that the intermolecular AAC reaction of an alkynyl selenium intermediate occurred. The resulting multisubstituted 5-seleno-1,2,3-triazoles were tested for in vitro anticancer activity by MTT assay, and compounds 4f, 4h, and 4p showed potent cancer cell-growth inhibition activities.Entities:
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Year: 2018 PMID： 29388780 DOI： 10.1021/acs.orglett.7b03734
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005