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Literature DB >> 29388567

Nitric oxide signalling in cardiovascular health and disease.

Charlotte Farah¹, Lauriane Y M Michel¹, Jean-Luc Balligand¹.

Abstract

Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in cardiovascular homeostasis. Tremendous knowledge has been accumulated on the mechanisms of the nitric oxide synthase (NOS)-NO pathway, but how this highly reactive, free radical gas signals to specific targets for precise regulation of cardiovascular function remains the focus of much intense research. In this Review, we summarize the updated paradigms on NOS regulation, NO interaction with reactive oxidant species in specific subcellular compartments, and downstream effects of NO in target cardiovascular tissues, while emphasizing the latest developments of molecular tools and biomarkers to modulate and monitor NO production and bioavailability.

Entities: Chemical Disease Gene

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Year: 2018 PMID： 29388567 DOI： 10.1038/nrcardio.2017.224

Source DB: PubMed Journal: Nat Rev Cardiol ISSN： 1759-5002 Impact factor: 32.419

473 in total

1. Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans.

Authors: M T Gladwin; J H Shelhamer; A N Schechter; M E Pease-Fye; M A Waclawiw; J A Panza; F P Ognibene; R O Cannon
Journal: Proc Natl Acad Sci U S A Date: 2000-10-10 Impact factor: 11.205

2. Site-specific microRNA-92a regulation of Kruppel-like factors 4 and 2 in atherosusceptible endothelium.

Authors: Yun Fang; Peter F Davies
Journal: Arterioscler Thromb Vasc Biol Date: 2012-01-19 Impact factor: 8.311

3. Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia.

Authors: Yalda Jamshidi; Ilja M Nolte; Chrysoula Dalageorgou; Dongling Zheng; Toby Johnson; Rachel Bastiaenen; Suzanne Ruddy; Daniel Talbott; Kris J Norris; Harold Snieder; Alfred L George; Vanessa Marshall; Saad Shakir; Prince J Kannankeril; Patricia B Munroe; A John Camm; Steve Jeffery; Dan M Roden; Elijah R Behr
Journal: J Am Coll Cardiol Date: 2012-06-06 Impact factor: 24.094

4. Novel Angiogenic Activity and Molecular Mechanisms of ZYZ-803, a Slow-Releasing Hydrogen Sulfide-Nitric Oxide Hybrid Molecule.

Authors: Qingxun Hu; Dan Wu; Fenfen Ma; Suna Yang; Bo Tan; Hong Xin; Xianfeng Gu; Xu Chen; Siyao Chen; Yicheng Mao; Yi Zhun Zhu
Journal: Antioxid Redox Signal Date: 2016-06-29 Impact factor: 8.401

5. Liposomal tetrahydrobiopterin preserves eNOS coupling in the post-ischemic heart conferring in vivo cardioprotection.

Authors: Lin Xie; M A Hassan Talukder; Jian Sun; Saradhadevi Varadharaj; Jay L Zweier
Journal: J Mol Cell Cardiol Date: 2015-06-25 Impact factor: 5.000

Review 6. Caveolin1/protein arginine methyltransferase1/sirtuin1 axis as a potential target against endothelial dysfunction.

Authors: Soniya Charles; Vijay Raj; Jesu Arokiaraj; Kanchana Mala
Journal: Pharmacol Res Date: 2017-01-23 Impact factor: 7.658

7. Mechanisms underlying erythrocyte and endothelial nitrite reduction to nitric oxide in hypoxia: role for xanthine oxidoreductase and endothelial nitric oxide synthase.

Authors: Andrew J Webb; Alexandra B Milsom; Krishnaraj S Rathod; Wai Lum Chu; Shehla Qureshi; Matthew J Lovell; Florence M J Lecomte; David Perrett; Carmelo Raimondo; Espeed Khoshbin; Zubair Ahmed; Rakesh Uppal; Nigel Benjamin; Adrian J Hobbs; Amrita Ahluwalia
Journal: Circ Res Date: 2008-09-25 Impact factor: 17.367

8. Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice.

Authors: Nicholas J Alp; Martina A McAteer; Jeffrey Khoo; Robin P Choudhury; Keith M Channon
Journal: Arterioscler Thromb Vasc Biol Date: 2004-01-05 Impact factor: 8.311

9. Soluble guanylate cyclase as an alternative target for bronchodilator therapy in asthma.

Authors: Arnab Ghosh; Cynthia J Koziol-White; Kewal Asosingh; Georgina Cheng; Lisa Ruple; Dieter Groneberg; Andreas Friebe; Suzy A A Comhair; Johannes-Peter Stasch; Reynold A Panettieri; Mark A Aronica; Serpil C Erzurum; Dennis J Stuehr
Journal: Proc Natl Acad Sci U S A Date: 2016-04-11 Impact factor: 11.205

Review 10. Folic Acid Supplementation and the Risk of Cardiovascular Diseases: A Meta-Analysis of Randomized Controlled Trials.

Authors: Yanping Li; Tianyi Huang; Yan Zheng; Tauland Muka; Jenna Troup; Frank B Hu
Journal: J Am Heart Assoc Date: 2016-08-15 Impact factor: 5.501

108 in total

1. Hsp70:CHIP Ubiquitinates Dysfunctional but Not Native Neuronal NO Synthase.

Authors: Amanda K Davis; Natalie F McMyn; Miranda Lau; Yoshihiro Morishima; Yoichi Osawa
Journal: Mol Pharmacol Date: 2020-06-26 Impact factor: 4.436

Review 2. Cardiac β₃ -adrenoceptors-A role in human pathophysiology?

Authors: Ebru Arioglu-Inan; Gizem Kayki-Mutlu; Martin C Michel
Journal: Br J Pharmacol Date: 2019-04-22 Impact factor: 8.739

Review 3. Leveraging Signaling Pathways to Treat Heart Failure With Reduced Ejection Fraction.

Authors: Miguel Pinilla-Vera; Virginia S Hahn; David A Kass
Journal: Circ Res Date: 2019-05-24 Impact factor: 17.367

4. Perturbations of the arginine metabolome following exposures to traffic-related air pollution in a panel of commuters with and without asthma.

Authors: Donghai Liang; Chandresh N Ladva; Rachel Golan; Tianwei Yu; Douglas I Walker; Stefanie E Sarnat; Roby Greenwald; Karan Uppal; ViLinh Tran; Dean P Jones; Armistead G Russell; Jeremy A Sarnat
Journal: Environ Int Date: 2019-04-10 Impact factor: 9.621

Review 5. Environmentally responsive hydrogels for repair of cardiovascular tissue.

Authors: Shuaimeng Guan; Jiankang Li; Kun Zhang; Jingan Li
Journal: Heart Fail Rev Date: 2021-09 Impact factor: 4.214

6. Interaction among Hydrogen Sulfide and Other Gasotransmitters in Mammalian Physiology and Pathophysiology.

Authors: Ya-Qian Huang; Hong-Fang Jin; Heng Zhang; Chao-Shu Tang; Jun-Bao Du
Journal: Adv Exp Med Biol Date: 2021 Impact factor: 2.622

7. Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO•) and Nitroxyl (HNO), in the Setting of Reactive Oxygen Species Dysregulation.

Authors: Barbara K Kemp-Harper; Anida Velagic; Nazareno Paolocci; John D Horowitz; Rebecca H Ritchie
Journal: Handb Exp Pharmacol Date: 2021

Nitric oxide signalling in cardiovascular health and disease.

1. Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans.

2. Site-specific microRNA-92a regulation of Kruppel-like factors 4 and 2 in atherosusceptible endothelium.

3. Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia.

4. Novel Angiogenic Activity and Molecular Mechanisms of ZYZ-803, a Slow-Releasing Hydrogen Sulfide-Nitric Oxide Hybrid Molecule.

5. Liposomal tetrahydrobiopterin preserves eNOS coupling in the post-ischemic heart conferring in vivo cardioprotection.

Review 6. Caveolin1/protein arginine methyltransferase1/sirtuin1 axis as a potential target against endothelial dysfunction.

7. Mechanisms underlying erythrocyte and endothelial nitrite reduction to nitric oxide in hypoxia: role for xanthine oxidoreductase and endothelial nitric oxide synthase.

8. Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice.

9. Soluble guanylate cyclase as an alternative target for bronchodilator therapy in asthma.

Review 10. Folic Acid Supplementation and the Risk of Cardiovascular Diseases: A Meta-Analysis of Randomized Controlled Trials.

1. Hsp70:CHIP Ubiquitinates Dysfunctional but Not Native Neuronal NO Synthase.

Review 2. Cardiac β₃ -adrenoceptors-A role in human pathophysiology?

Review 3. Leveraging Signaling Pathways to Treat Heart Failure With Reduced Ejection Fraction.

4. Perturbations of the arginine metabolome following exposures to traffic-related air pollution in a panel of commuters with and without asthma.

Review 5. Environmentally responsive hydrogels for repair of cardiovascular tissue.

6. Interaction among Hydrogen Sulfide and Other Gasotransmitters in Mammalian Physiology and Pathophysiology.

7. Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO•) and Nitroxyl (HNO), in the Setting of Reactive Oxygen Species Dysregulation.

8. Nitric oxide synthase inhibitors negatively regulate respiration in isolated rodent cardiac and brain mitochondria.

9. Structural insights into the mechanism of human soluble guanylate cyclase.

Review 10. Role of PI3K/Akt signaling pathway in cardiac fibrosis.

Review 6. Caveolin1/protein arginine methyltransferase1/sirtuin1 axis as a potential target against endothelial dysfunction.

Review 10. Folic Acid Supplementation and the Risk of Cardiovascular Diseases: A Meta-Analysis of Randomized Controlled Trials.

Review 2. Cardiac β3 -adrenoceptors-A role in human pathophysiology?

Review 3. Leveraging Signaling Pathways to Treat Heart Failure With Reduced Ejection Fraction.

Review 5. Environmentally responsive hydrogels for repair of cardiovascular tissue.

Review 10. Role of PI3K/Akt signaling pathway in cardiac fibrosis.

Review 2. Cardiac β₃ -adrenoceptors-A role in human pathophysiology?