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Literature DB >> 29388431

Diverted Total Synthesis of the Baulamycins and Analogues Reveals an Alternate Mechanism of Action.

Andrew D Steele¹, Guillaume Ernouf¹, Young Eun Lee², William M Wuest¹.

Abstract

The baulamycins were identified as in vitro siderophore biosynthesis inhibitors. Diverted total synthesis was used to construct the natural products and eight strategic analogues, three of which had improved inhibitory activity. Biological testing then revealed that membrane damage is the predominant mode of action in Staphylococcus aureus cells.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2018 PMID： 29388431 PMCID： PMC5869691 DOI： 10.1021/acs.orglett.8b00054

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

18 in total

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2. The antibiotic resistance crisis: part 1: causes and threats.

Authors: C Lee Ventola
Journal: P T Date: 2015-04

3. Diverted Total Synthesis of Carolacton-Inspired Analogs Yields Three Distinct Phenotypes in Streptococcus mutans Biofilms.

Authors: Amy E Solinski; Alexander B Koval; Richard S Brzozowski; Kelly R Morrison; Americo J Fraboni; Carrie E Carson; Anisa R Eshraghi; Guangfeng Zhou; Robert G Quivey; Vincent A Voelz; Bettina A Buttaro; William M Wuest
Journal: J Am Chem Soc Date: 2017-05-17 Impact factor: 15.419

4. Baulamycins A and B, broad-spectrum antibiotics identified as inhibitors of siderophore biosynthesis in Staphylococcus aureus and Bacillus anthracis.

Authors: Ashootosh Tripathi; Michael M Schofield; George E Chlipala; Pamela J Schultz; Isaiah Yim; Sean A Newmister; Tyler D Nusca; Jamie B Scaglione; Philip C Hanna; Giselle Tamayo-Castillo; David H Sherman
Journal: J Am Chem Soc Date: 2014-01-17 Impact factor: 15.419

5. The Story behind "Synergy of Synthesis, Computation, and NMR Reveals Correct Baulamycin Structures".

Authors: Paula Lorenzo; Craig P Butts; Eddie L Myers; Varinder K Aggarwal
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Review 6. Natural Products as Platforms To Overcome Antibiotic Resistance.

Authors: Sean E Rossiter; Madison H Fletcher; William M Wuest
Journal: Chem Rev Date: 2017-09-27 Impact factor: 60.622

Review 7. Resistance to antibiotics: are we in the post-antibiotic era?

Authors: Alfonso J Alanis
Journal: Arch Med Res Date: 2005 Nov-Dec Impact factor: 2.235

8. Systematic Asymmetric Synthesis of All Diastereomers of (-)-Talaumidin and Their Neurotrophic Activity.

Authors: Kenichi Harada; Miwa Kubo; Hiroki Horiuchi; Akiko Ishii; Tomoyuki Esumi; Hideaki Hioki; Yoshiyasu Fukuyama
Journal: J Org Chem Date: 2015-07-06 Impact factor: 4.354

9. Structural Revision of Baulamycin A and Structure-Activity Relationships of Baulamycin A Derivatives.

Authors: Sandip Sengupta; Munhyung Bae; Dong-Chan Oh; Uttam Dash; Hak Joong Kim; Woon Young Song; Injae Shin; Taebo Sim
Journal: J Org Chem Date: 2017-10-02 Impact factor: 4.354

10. Diverted Total Synthesis of Promysalin Analogs Demonstrates That an Iron-Binding Motif Is Responsible for Its Narrow-Spectrum Antibacterial Activity.

Authors: Andrew D Steele; Colleen E Keohane; Kyle W Knouse; Sean E Rossiter; Sierra J Williams; William M Wuest
Journal: J Am Chem Soc Date: 2016-04-28 Impact factor: 15.419

4 in total