Jacob D Bolzenius1, Carmen S Velez, Jeffrey D Lewis, Erin D Bigler, Benjamin S C Wade, Douglas B Cooper, Jan E Kennedy, Matthew W Reid, John L Ritter, Gerald E York, David F Tate. 1. Missouri Institute of Mental Health, University of Missouri-St Louis, Berkeley, Missouri (Drs Bolzenius, Wade, and Tate and Ms Velez); Department of Neurology, Uniformed Services University of the Health Sciences School of Medicine, Bethesda, Maryland (Dr Lewis); Department of Psychology and Neuroscience Center, Brigham Young University, Provo, Utah (Dr Bigler); Defense and Veterans Brain Injury Center, San Antonio, Texas (Drs Cooper, Kennedy, and Reid); Department of Radiology, Brooke Army Medical Center, San Antonio, Texas (Dr Ritter); and Alaska Radiology Associates, TBI Imaging and Research, Anchorage, Alaska (Dr York).
Abstract
OBJECTIVE: Use diffusion tensor imaging to investigate white matter microstructure attributable to mild TBI (mTBI) and/or posttraumatic stress disorder (PTSD). PARTICIPANTS: Twenty-seven individuals with mTBI only, 16 with PTSD only, 42 with mTBI + PTSD, and 43 service members who sustained orthopedic injury. DESIGN: Descriptive cross-sectional study. MAIN MEASURES: Clinical diffusion tensor imaging sequence to assess fractional anisotropy, mean, axial, and radial diffusivity within selected regions of interest. RESULTS: Corrected analyses revealed a pattern of lower white matter integrity in the PTSD group for several scalar metrics. Regions affected included primarily right hemisphere areas of the internal capsule. These differences associated with the PTSD only cohort were observed in relation to all 3 comparison groups, while the mTBI + PTSD group did not exhibit any notable pattern of white matter abnormalities. CONCLUSION: Results suggest that lower resolution scan sequences are sensitive to post-acute abnormalities associated with PTSD, particularly in the right hemisphere. In addition, these findings suggest that ongoing PTSD symptoms are associated with differences in white matter diffusion that are more readily detected in a clinical scan sequence than mTBI abnormalities. Future studies are needed to prospectively assess service members prior to onset of injury to verify this pattern of results.
OBJECTIVE: Use diffusion tensor imaging to investigate white matter microstructure attributable to mild TBI (mTBI) and/or posttraumatic stress disorder (PTSD). PARTICIPANTS: Twenty-seven individuals with mTBI only, 16 with PTSD only, 42 with mTBI + PTSD, and 43 service members who sustained orthopedic injury. DESIGN: Descriptive cross-sectional study. MAIN MEASURES: Clinical diffusion tensor imaging sequence to assess fractional anisotropy, mean, axial, and radial diffusivity within selected regions of interest. RESULTS: Corrected analyses revealed a pattern of lower white matter integrity in the PTSD group for several scalar metrics. Regions affected included primarily right hemisphere areas of the internal capsule. These differences associated with the PTSD only cohort were observed in relation to all 3 comparison groups, while the mTBI + PTSD group did not exhibit any notable pattern of white matter abnormalities. CONCLUSION: Results suggest that lower resolution scan sequences are sensitive to post-acute abnormalities associated with PTSD, particularly in the right hemisphere. In addition, these findings suggest that ongoing PTSD symptoms are associated with differences in white matter diffusion that are more readily detected in a clinical scan sequence than mTBI abnormalities. Future studies are needed to prospectively assess service members prior to onset of injury to verify this pattern of results.
Authors: Carrie Esopenko; Nicola L de Souza; Yuane Jia; J Scott Parrott; Tricia L Merkley; Emily L Dennis; Frank G Hillary; Carmen Velez; Douglas B Cooper; Jan Kennedy; Jeffrey Lewis; Gerald York; Deleene S Menefee; Stephen R McCauley; Amy O Bowles; Elisabeth A Wilde; David F Tate Journal: J Head Trauma Rehabil Date: 2022-04-21 Impact factor: 3.117
Authors: Neda Jahanshad; Rajendra A Morey; Emily L Dennis; Seth G Disner; Negar Fani; Lauren E Salminen; Mark Logue; Emily K Clarke; Courtney C Haswell; Christopher L Averill; Lee A Baugh; Jessica Bomyea; Steven E Bruce; Jiook Cha; Kyle Choi; Nicholas D Davenport; Maria Densmore; Stefan du Plessis; Gina L Forster; Jessie L Frijling; Atilla Gonenc; Staci Gruber; Daniel W Grupe; Jeffrey P Guenette; Jasmeet Hayes; David Hofmann; Jonathan Ipser; Tanja Jovanovic; Sinead Kelly; Mitzy Kennis; Philipp Kinzel; Saskia B J Koch; Inga Koerte; Sheri Koopowitz; Mayuresh Korgaonkar; John Krystal; Lauren A M Lebois; Gen Li; Vincent A Magnotta; Antje Manthey; Geoff J May; Deleene S Menefee; Laura Nawijn; Steven M Nelson; Richard W J Neufeld; Jack B Nitschke; Daniel O'Doherty; Matthew Peverill; Kerry J Ressler; Annerine Roos; Margaret A Sheridan; Anika Sierk; Alan Simmons; Raluca M Simons; Jeffrey S Simons; Jennifer Stevens; Benjamin Suarez-Jimenez; Danielle R Sullivan; Jean Théberge; Jana K Tran; Leigh van den Heuvel; Steven J A van der Werff; Sanne J H van Rooij; Mirjam van Zuiden; Carmen Velez; Mieke Verfaellie; Robert R J M Vermeiren; Benjamin S C Wade; Tor Wager; Henrik Walter; Sherry Winternitz; Jonathan Wolff; Gerald York; Ye Zhu; Xi Zhu; Chadi G Abdallah; Richard Bryant; Judith K Daniels; Richard J Davidson; Kelene A Fercho; Carol Franz; Elbert Geuze; Evan M Gordon; Milissa L Kaufman; William S Kremen; Jim Lagopoulos; Ruth A Lanius; Michael J Lyons; Stephen R McCauley; Regina McGlinchey; Katie A McLaughlin; William Milberg; Yuval Neria; Miranda Olff; Soraya Seedat; Martha Shenton; Scott R Sponheim; Dan J Stein; Murray B Stein; Thomas Straube; David F Tate; Nic J A van der Wee; Dick J Veltman; Li Wang; Elisabeth A Wilde; Paul M Thompson; Peter Kochunov Journal: Mol Psychiatry Date: 2019-12-19 Impact factor: 15.992