David Krug1,2, René Baumann3, Wilfried Budach4, Jürgen Dunst3, Petra Feyer5, Rainer Fietkau6, Wulf Haase7, Wolfgang Harms8, Thomas Hehr9, Marc D Piroth10, Felix Sedlmayer11, Rainer Souchon12, Frederik Wenz13, Rolf Sauer6. 1. Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany. david.krug@med.uni-heidelberg.de. 2. Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany. david.krug@med.uni-heidelberg.de. 3. University Hospital Schleswig-Holstein, Kiel, Germany. 4. Heinrich-Heine-University, Duesseldorf, Germany. 5. Vivantes Hospital Neukoelln, Berlin, Germany. 6. University Hospital Erlangen, Erlangen, Germany. 7. Formerly St.-Vincentius-Hospital, Karlsruhe, Germany. 8. St. Claraspital, Basel, Switzerland. 9. Department of Radiation Oncology, Marienhospital Stuttgart, Stuttgart, Germany. 10. HELIOS-Hospital Wuppertal, Witten/Herdecke University, Wuppertal, Germany. 11. Paracelsus Medical University Hospital, Salzburg, Austria. 12. Formerly University Hospital Tuebingen, Tuebingen, Germany. 13. Universitätsmedizin Mannheim, Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim, Germany.
Abstract
PURPOSE: To review the evidence regarding post-mastectomy radiotherapy (PMRT) and regional nodal irradiation (RNI) after neoadjuvant chemotherapy (NACT) for breast cancer, with a special focus on individualization of adjuvant radiotherapy based on treatment response. METHODS: A systematic literature search using the PubMed/Medline database was performed. We included prospective and retrospective reports with a minimum of 10 patients that had been published since 1st January 2000, and provided clinical outcome data analyzed by treatment response and radiotherapy. RESULTS: Out of 763 articles identified via PubMed/Medline and hand search, 68 full text-articles were assessed for eligibility after screening of title and abstract. 13 studies were included in the systematic review, 9 for PMRT and 5 for RNI. All included studies were retrospective reports. CONCLUSIONS: There is a considerable lack of evidence regarding the role of adjuvant radiotherapy and its individualization based on treatment response after NACT. Results of prospective randomized trials such as NSABP B‑51/RTOG 1304 and Alliance A11202 are eagerly awaited.
PURPOSE: To review the evidence regarding post-mastectomy radiotherapy (PMRT) and regional nodal irradiation (RNI) after neoadjuvant chemotherapy (NACT) for breast cancer, with a special focus on individualization of adjuvant radiotherapy based on treatment response. METHODS: A systematic literature search using the PubMed/Medline database was performed. We included prospective and retrospective reports with a minimum of 10 patients that had been published since 1st January 2000, and provided clinical outcome data analyzed by treatment response and radiotherapy. RESULTS: Out of 763 articles identified via PubMed/Medline and hand search, 68 full text-articles were assessed for eligibility after screening of title and abstract. 13 studies were included in the systematic review, 9 for PMRT and 5 for RNI. All included studies were retrospective reports. CONCLUSIONS: There is a considerable lack of evidence regarding the role of adjuvant radiotherapy and its individualization based on treatment response after NACT. Results of prospective randomized trials such as NSABP B‑51/RTOG 1304 and Alliance A11202 are eagerly awaited.
Entities:
Keywords:
Breast neoplasms; Local recurrence; Neoadjuvant therapy; Radiotherapy
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